Improvement of nortropine synthesizing process

Abstract

The invention discloses an improvement method of a nortropine synthesizing process. In the method, tropine and ethyl chloroformate are adopted as raw materials to synthesize nortropine. By adjusting the experimental operating steps, the method achieves the effects of moderate reaction condition, safe, simple as well as convenient operation, good product quality, and low cost.

Description

technical field [0001] The invention belongs to the technical field of drug synthesis, and in particular relates to a method for improving the synthesis process of nortropine alcohol. Background technique [0002] Overactive bladder (OAB) is a common and distressing problem, a common disease that affects the normal life of people of different ages, both men and women, especially women and the elderly. At present, the incidence rate of this disease is very high. According to the survey in Beijing area of ​​my country, the incidence rate of urinary incontinence in men over 50 years old is 16.4%, and the total incidence rate of mixed urinary incontinence and urge urinary incontinence in women over 18 years old is as high as 40.4%. [0003] Trospium chloride is a quaternary ammonium compound and belongs to the anticholinergic class of muscarinic receptor blockers. These drugs relax bladder smooth muscle, thereby reducing bladder contractions, and can be used as long-term treatm...

AI Technical Summary

Problems solved by technology

The problem that this preparation method exists is that chloroform can react with alkali to generate active intermediate dichlorocarbene under the condition that strong alkali exists, and side reaction occurs; In the synthetic method disclosed by this patent, weak base sodium bicarbonate is used, but in It is still easy to generate dichlorocarbene under the condition of heating and reflux, which affects the purity of the product