Method for detection of illegally added chemical in traditional Chinese medicine preparation

Abstract

The invention discloses a method for detection of an illegally added chemical in a traditional Chinese medicine preparation, which comprises the following steps: (1) carrying out thin-layer chromatography simultaneously for both sample solution containing a traditional Chinese medicine preparation to be detected and a reference substance of a chemical suspected of being illegally added; and (2) if the thin-layer chromatogram of the sample solution containing the traditional Chinese medicine preparation to be detected has spots in positions corresponding to the positions of the spots of the reference substance, performing infrared spectrum analysis for both silica gel in the positions with the spots of the traditional Chinese medicine preparation to be detected and silica gel in the positions with the spots of the reference substance, and then determining whether the traditional Chinese medicine preparation to be detected contains the chemical suspected of being illegally added. The invention can rapidly and accurately judge whether the traditional Chinese medicine preparation contains the illegally added chemical, and provides a novel method and means for detection of present adulteration of the traditional Chinese medicine preparation.

Description

technical field [0001] The invention relates to a method for detecting whether chemicals are illegally added to traditional Chinese medicine preparations. Background technique [0002] At present, some counterfeiters take advantage of the complex ingredients and imperfect quality standards of traditional Chinese medicine preparations to illegally add chemical drugs with similar effects in the production process of traditional Chinese medicine preparations, so that Chinese medicine preparations can achieve quick and effective therapeutic effects, thereby reaping high profits. profit. In order to effectively supervise, curb and crack down on the illegal behavior of illegally adding chemicals to Chinese patent medicines and ensure the drug safety of the general public, it is necessary to establish a technical platform for the detection of illegally adding chemicals to Chinese medicine preparations as soon as possible. [0003] Because the range of chemicals that may be added i...

AI Technical Summary

Problems solved by technology

Among them, the TLC method is widely used in the preliminary screening and rapid inspection of samples because of its simplicity, intuition, and short separation time, but it is prone to false "positive" interference, and the detection results need further analysis and verification. HPLC-MS, GC-MS At present, it has basically become the ultimate confirmation method for chemical drugs adulterated in traditional Chinese medicine in various countries and regions. However, due to the high purchase and maintenance costs of liquid-mass (gas-mass) spectrometers, there are certain difficulties in popularization and use.

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