Locally administrated low doses of corticosteroids

A corticosteroid, site-based technology, used in antipyretics, anti-inflammatory agents, drug combinations, etc., to solve problems such as lack of guidelines

Inactive Publication Date: 2010-06-30
WARSAW ORTHOPEDIC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no set guidelines for this approach, and complications are related to large boluses of steroids used to reduce neuropathic pain

Method used

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  • Locally administrated low doses of corticosteroids
  • Locally administrated low doses of corticosteroids
  • Locally administrated low doses of corticosteroids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0098] Preparation and release rate of 15% fluocinonide acetonide in PLGA particles

[0099] To prepare a biodegradable drug depot containing 15% fluocinolone PLGA, approximately 50 grams of 85 / 15 poly(D,L-lactide-co-glycolide) (PLGA) (Lakeshore Biomaterials, Birmingham, AL ) and 0.75 dL / g of IV with a molecular weight of 117 kDa were placed in a polypropylene beaker and cooled with liquid nitrogen (approximately 200 mL) for 10 minutes. The polymer was then milled to fine particles with an average diameter of approximately 80 microns using an UltraCentrifugal Mill ZM 200 (Retsch GmbH & Co., Haan, Germany). The ground polymer particles were collected and placed in a 10 cm aluminum weigh pan. The discs were placed in a vacuum oven at 35°C for 24 hours under vacuum to remove any condensation from the milling process.

[0100] Next, 3.5 grams of polymer was weighed into an aluminum weigh pan using an analytical balance. 0.7 g of fluocinonide acetonide (Spectrum Chemical, Garden...

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Abstract

This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot.

Description

technical field [0001] The present invention provides the use of locally delivered low dose corticosteroids for the treatment of pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, articular surface pain, osteoarthritis, Rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, locally delivered low-dose corticosteroids can be released by pumps or biodegradable drug depots into the epidural, perineural, or foramenal space of the patient at or near the site of pain . Background technique [0002] Pain is associated with many medical conditions and affects millions of Americans. The American Pain Foundation reports that more than 50 million Americans suffer from chronic pain, including 20% ​​of those 60 and older who suffer from joint (arthritis or other disease) and back pain. Additionally, nearly 25 million Americans experience acute pain each year as a re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16
CPCA61K31/56A61K9/0024A61K31/566A61P25/04A61P29/00A61K31/573A61K31/58
Inventor W·F·麦克凯J·M·扎内拉C·M·霍博特
Owner WARSAW ORTHOPEDIC INC
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