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Ciclesonide capsule type inhalation aerosol powder and preparation method thereof

A technology of ciclesonide and powder aerosol, which is applied in the field of inhalation powder aerosol and its preparation, which can solve the problems affecting the treatment effect, achieve good lung deposition rate, facilitate storage, and save energy and materials

Inactive Publication Date: 2010-07-07
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the experiment, we found that the lung deposition rate of the powder aerosol ciclesonide prepared according to the technical scheme disclosed in this invention is only 15% to 17%, and, because the particle size of the powder is too small, after a certain After a long period of storage, it is very easy to cause particle aggregation due to static electricity and affect the therapeutic effect

Method used

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  • Ciclesonide capsule type inhalation aerosol powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0025] Dissolve 0.2 g of ciclesonide in ethanol, filter, spray-dry the filtrate, and micronize the average particle size to 2 μm, and micronize 10 g of lactose to an average particle size of 20 μm with a flow energy mill, mix and pass through a 200-mesh sieve After mixing for 3 times, divide into No. 3 capsules.

Embodiment 1-2

[0027] According to the formula of Example 1-1, the ciclesonide was micronized with a flow energy mill to make the average particle size reach 1 μm, and the carrier was changed to octaacetate-D-cellobiose ester with an average particle size of 25 μm, according to Example 1 -1 process to prepare powder spray.

Embodiment 2-1

[0029] Dissolve 0.1 g of ciclesonide in ethanol. After filtration, the filtrate is spray-dried and micronized so that the average particle size reaches 4 μm. Lactose 20 g is micronized by a fluid energy mill to an average particle size of 30 μm. Sieve 3 times and mix evenly, then pack into No. 3 capsules.

[0030] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention discloses ciclesonide capsule type inhalation aerosol powder and a preparation method thereof. The ciclesonide capsule type inhalation aerosol powder can improve the deposition rate of ciclesonide in the inhalation aerosol powder in lung, avoid the deposition of carrier micropowder in the lung, improve the stability of a composition and consists of an active component and micropowder of a carrier and is characterized in that the average particle diameter of the micropowder as the active component is 0.5-10mu m and the average particle diameter of the micropowder of the carrier is 20-45mu m.

Description

Technical field: [0001] The invention relates to a medicine for treating respiratory diseases, especially asthma, in particular to an inhalation powder spray and a preparation method thereof. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. The current drugs for the treatment of asthma and other lung diseases mainly include the following: [0003] (1) β2-receptor agonists [0004] (2) Xanthine ...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/14A61K31/58A61P11/06
Inventor 张其婉李静
Owner TIANJIN JINYAO GRP
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