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Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy

A technology for diabetic nephropathy and total flavonoids is applied in the application field of astragalus total flavonoids in the preparation of medicines for preventing and treating diabetic nephropathy, and can solve the problems of no reports and the like

Active Publication Date: 2010-07-07
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although it has been reported in the literature that it has various pharmacological activities, however, there is no report at home and abroad on the effect of total flavonoids of Astragalus on the prevention and treatment of diabetic nephropathy.

Method used

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  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy
  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy
  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of total flavonoids of astragalus and monomer compounds

[0021] Take 10 kg of dried astragalus medicinal materials, extract 3 times with 8 times the amount of 80% ethanol (2 hours, 1 hour, 1 hour), filter, combine the filtrates, recover the solvent under reduced pressure, and concentrate until there is no alcohol smell to obtain the astragalus alcoholic extract, Store in a refrigerator at 4°C for 2 days. The supernatant was adsorbed with D101 macroporous resin, firstly eluted with pure water until the effluent was clear, and then eluted with 50% ethanol until no verfolavone glycoside spots were detected by TLC. The 50% ethanol eluate was collected and concentrated under reduced pressure, extracted 7 times with an equal volume of ethyl acetate, the extracts were combined, the solvent was recovered, and vacuum-dried to obtain total astragalus flavonoids. The content of total flavonoids detected by UV spectrophotometry was 54.3%.

[0022] The total ...

Embodiment 2

[0023] Example 2 Preparation of total flavonoids of astragalus and monomer compounds

[0024] Take 100kg of dried astragalus medicinal materials, extract 3 times (2 hours, 1 hour, 0.5 hours) with 10 times the amount of 80% ethanol, 5 times the amount of 60% ethanol, and 5 times the amount of 90% ethanol respectively (2 hours, 1 hour, 0.5 hours), filter, combine the filtrates, and reduce the pressure The solvent was recovered and concentrated until there was no alcohol smell to obtain astragalus alcoholic extract, which was refrigerated in a 4°C refrigerator for 1 day. The supernatant was adsorbed with AB-8 type macroporous resin, first eluted with pure water until the effluent was clear, and then used 40% ethanol was used to elute until there were no velocinoin spots detected by TLC. The 40% ethanol eluate was collected and concentrated under reduced pressure, extracted 7 times with an equal volume of ethyl acetate, the extracts were combined, the solvent was recovered, and va...

Embodiment 3

[0026] Example 3 Capsules (tablets) containing astragalus total flavonoids

[0027] Formulation prescription:

[0028] Astragalus Total Flavonoids 80g

[0029] Microcrystalline fiber 80g

[0030] Starch 20g

[0031] Lactose 18g

[0032] Dextrin 2g

[0033] Preparation method: take the total flavonoids extract of Astragalus membranaceus prepared in Example 1, pulverize, pass through an 80-mesh sieve, mix with the above-mentioned auxiliary materials, granulate with 80% ethanol, and granulate; take half of the capsules and make 500 capsules; Half are pressed into tablets to make 500 tablets.

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Abstract

The invention relates to the pharmacy field of traditional Chinese medicines, in particular to application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy. The invention investigates the influence of the total flavonoid in astragalus on the cell proliferation and the cell extracellular matrix hyperplasia of a glomerulus mesentery of a rat as well as the therapeutic effect of the total flavonoid in astragalus on a mouse with the diabetes and the nephropathy; and the experimental result proves that the total flavonoid in astragalus has remarkable treating and preventing functions on the diabetes and the nephropathy, thus the invention provides application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy and a medicinal composition which contains the total flavonoid in astragalus and is used for preventing and controlling the diabetes and the nephropathy, and thereby providing a new medicine choice for treating and preventing the diabetes and the nephropathy.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to the application of total flavonoids of astragalus in the preparation of medicines for preventing and treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN), also known as "diabetic glomerulosclerosis", is a common complication of diabetes and one of the manifestations of systemic microangiopathy in diabetes, usually due to the thickening of the glomerular basement membrane caused by diabetes. Mesangial expansion and extracellular matrix proliferation, leading to glomerulosclerosis. Mesangial cell lesions play an extremely important role in the occurrence and development of diabetic nephropathy. Glomerular mesangial cells are the main component of the glomerulus, accounting for about 30-40% of the total number of glomerular cells. Glomerular mesangial cells have a variety of functions, such as secreting cellular matrix, producin...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P3/10A61P13/12
Inventor 朱荃石兴华汤丹郑兆广何宝段婷婷顾斐程慧荃黄晓玲黄艳霞王汝上
Owner 广州康臣药业有限公司
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