Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof

A composition and stroke technology, applied in the field of medicine, to achieve the effect of controllable quality and clear drug effect

Inactive Publication Date: 2010-07-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature report on the combined use of astragalus, salvia miltiorrhiza, and chuanxiong in the treatment of stroke

Method used

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  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof
  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof
  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 medicine of the present invention:

[0027] a. Take 50 kg of Astragalus membranaceus, 50 kg of Salvia miltiorrhiza, 50 kg of Rhizoma Chuanxiong, extract the decoction pieces of Astragalus membranaceus with 30% ethanol, pass the filtrate through a macroporous resin column, elute with 30% ethanol, reclaim ethanol, and obtain total saponins of Astragalus;

[0028] B, the preparation of Danshen ethanol extract: Danshen decoction pieces are heated and extracted with 8 times of water, and the extract is passed through a macroporous resin column (D 101 ), eluted with 50% ethanol, reclaimed ethanol, and obtained salvia miltiorrhiza phenolic acid; dregs were recovered and extracted with 95% ethanol, recovered ethanol, obtained salvia miltiorrhiza ketone extract, mixed salvia miltiorrhiza total phenolic acid and salvia miltiorrhiza total ketone extract, obtained Danshen alcohol extract;

[0029] c, the decoction pieces of Chuanxiong are extracted ...

Embodiment 2

[0031] The preparation of embodiment 2 medicines of the present invention

[0032] a. Take 120kg of Astragalus membranaceus, 50kg of Salvia miltiorrhiza, 50kg of Rhizoma Chuanxiong, extract the decoction pieces of Astragalus membranaceus with 60% ethanol, pass the filtrate through a macroporous resin column, elute with 70% ethanol, reclaim ethanol, and obtain total saponins of Astragalus membranaceus;

[0033] b. Preparation of the alcoholic extract of Salvia miltiorrhiza: extract by heating the decoction pieces of Salvia miltiorrhiza with 15 times of water, pass the extract through a macroporous resin column, elute with 90% ethanol, recover the ethanol, and obtain the total phenolic acid of Salvia miltiorrhiza; recover and extract the dregs with absolute ethanol, recovering ethanol to obtain the total ketone extract of salvia miltiorrhiza, mixing the total phenolic acids of salvia miltiorrhiza with the total ketone extract of salvia miltiorrhiza to obtain the ethanol extract o...

Embodiment 3

[0036] Embodiment 3 preparation of medicine of the present invention

[0037] Get Radix Astragali 30kg, Salvia Miltiorrhiza 15kg, Rhizoma Chuanxiong 10kg, prepare granules by the method of Example 1.

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PUM

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Abstract

The invention provides a pharmaceutical composite for treating cerebral stroke, which is prepared from the following ingredients in portion by weight: 5-120 portions of radix astragali, 5-50 portions of radix salviae miltiorrhizae and 5-50 portions of ligusticum chuanxiong. The invention further provides a preparation method thereof. The medicine, due to the adoption of middle cerebral artery occlusion model (MCAO model) and the application of modern histopathology, flow cytometry and molecular biotechnology, has the effect of blocking inflammatory reaction in ischemic infarction area. Through experiment, the result shows that, due to the compatibility of three ingredients, the medicine has the advantages of obvious synergism, definite efficacy and controllable quality, thereby clinically providing a new medicine for treating cerebral stroke.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cerebral apoplexy, which belongs to the field of medicine. Background technique [0002] Cerebrovascular disease is one of the main diseases that seriously endanger human life and health in the world today, and it is a common and frequently-occurring disease in our country. Stroke is a serious manifestation of various cerebrovascular diseases, with high disability rate and high mortality rate. Stroke has always been the main cause of death in China. The average age-standardized incidence rate of acute stroke events in the 25-74 age group is 270 / 100,000 males and 161 / 100,000 females, and the average age-standardized mortality rate is 89 / 100,000 males and 61 / 10 females million, the average age-standardized case fatality rate was 33% for men and 38% for women. It not only seriously threatens the lives of patients and affects their quality of life, but also brings heavy burdens to familie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 陈卫银严铸云祝彼得刘福友冉宁晶金硕果余芳谢文
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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