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Metal anastomotic nail absorbable in vivo and preparation method thereof

A staple and metal technology, applied in the field of in vivo absorbable metal staples and its preparation, can solve problems such as non-degradability, achieve good biocompatibility, and ensure biological safety

Inactive Publication Date: 2010-07-07
CHANGSHU MICROTUBE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this prior art only designed the external dimensions, and its essence is still the traditional non-degradable nail

Method used

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  • Metal anastomotic nail absorbable in vivo and preparation method thereof
  • Metal anastomotic nail absorbable in vivo and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Melting 94wt% Mg-6wt% Zn alloy, heat treatment at 350°C for 3 hours and then hot extruding into a primary billet, the extrusion temperature is 200°C. Finally, absorbable metal staples are machined.

[0025] The body 1 of the absorbable metal staple prepared in this embodiment is 4 mm long, the nail foot 2 is 30 mm long, and the nail foot has a pointed head. The section is circular with a diameter of 0.6mm.

Embodiment 2

[0027] Melting 99wt% Mg-1wt% Ca alloy, heat treatment at 400°C for 3 hours and then hot extruding into a primary billet at an extrusion temperature of 250°C. Finally, absorbable metal staples are machined.

[0028] The cross-sectional shape of the absorbable metal staple prepared in this example is a square with a side length of 0.4 mm. The length of the nail body is 3.5mm, the length of the nail foot is 4mm, and the end of the nail foot has a pointed end. The nail was soaked in 1 liter of simulated body fluid in vitro, and its weight degraded by 10% after one week.

Embodiment 3

[0030] Melting 99wt% Mg-3wt% Zn-0.8wt% Mn alloy, heat treatment at 400°C for 3 hours and then hot extruding into a primary billet, the extrusion temperature is 250°C. Finally, an absorbable metal staple with a circular cross section is machined.

[0031] The absorbable staple prepared in this example has a body length of 10 mm, a nail foot length of 8 mm, and a pointed head with a cross-sectional diameter of 0.9 mm. Among them, the three-point bending strength of the nail body is 500MPa. The weight loss rate was 20% after soaking in normal saline in vitro for 1 week, and the three-point bending strength of the nail body was found to be around 400MPa after testing. It proves that certain mechanical properties can be maintained during the degradation process, which can meet the mechanical requirements of the incision healing process.

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Abstract

The invention relates to a metal anastomotic nail absorbable in vivo and a preparation method thereof, which belong to the technical field of medical appliances. The metal anastomotic nail has a U-shaped structure and comprises a nail body and two nail legs which are arranged at two ends of the nail body respectively; and the anastomotic nail is made of magnesium alloy. The magnesium alloy comprises the following components in percentage by weight: 0.01 to 10 percent of Zn, 0.01 to 5 percent of Ca, 0.001 to 5 percent of Fe, 0.01 to 5 percent of Mn and the balance of Mg. The metal anastomotic nail can be continuously absorbed and has good biocompatibility.

Description

technical field [0001] The invention relates to a device in the technical field of medical devices, in particular to an in vivo absorbable metal staple and a preparation method thereof. Background technique [0002] Staples are medical devices currently used in clinical medicine to replace traditional manual sutures. They are easy to use, fast to suture during surgery, and easy to operate. They can significantly shorten tissue exposure time, reduce trauma and bleeding, and effectively reduce surgical complications. The staple materials currently used in clinical practice mainly include stainless steel, titanium and titanium alloys. These metal materials are all inert materials and cannot be degraded in the human body, so the staples will permanently exist as foreign objects in the human body, slowly releasing debris or even toxic and irritating ions, causing severe inflammatory reactions in the surrounding tissues and reducing the quality of the device. biocompatibility and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/06A61B17/04
Inventor 张绍翔李佳楠赵常利张小农
Owner CHANGSHU MICROTUBE TECH
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