Compound hemostasis medicine and preparation method thereof

Abstract

The invention provides a compound hemostasis medicine, namely a compound adrenal color hydrazone enteric capsule formulation or granular formulation, mainly containing adrenal color hydrazone, vitamin K1, vitamin C and pharmaceutic adjuvants. By using the invention, the defect lacking of blood coagulation function for the existing adrenal color hydrazone hemostasis medicine is solved to reduce blood capillary permeability and enable an injured blood capillary end to retract to realize hemostasis effect; vitamin K1 is used for affecting some blood coagulation factors and promoting or restoring blood coagulation process to speed up hemostasis; vitamin C containing synthetical collagen and histocyte is used for repairing injured blood capillary wall in time, stimulating blood coagulation function and promoting wound to heal; and the enteric formulation enables the medicine to release in intestines to effectively reduce stomach stimulation and adverse reaction of salicylic acid reaction caused by adrenal color hydrazone release in stomach. The invention also provides a method for preparing the compound adrenal color hydrazone enteric capsule formulation or granular formulation.

Description

technical field [0001] The invention belongs to a compound medicine preparation containing organic active ingredients, in particular to a compound hemostatic drug, namely a compound adrenal color hydrazone enteric-coated capsule or enteric-coated granule and a preparation method thereof Background technique [0002] Carbazochrome, also known as Carbazochrome, Anluoxue, is a sodium salt of adrenaline oxide adrenochrome. Its oral dosage form is sugar-coated tablets. For bleeding caused by capillary damage and increased permeability, such as epistaxis. Retinal hemorrhage, hemoptysis, gastrointestinal bleeding, hematuria, hemorrhoids and uterine bleeding, etc. Also used for thrombocytopenic purpura, but the hemostatic effect is not very satisfactory. The reason for the unsatisfactory hemostatic effect is that adrenal hydrazone cannot participate in or promote the recovery of coagulation process by affecting certain coagulation factors after blood vessel or tissue injury, but c...

AI Technical Summary

Problems solved by technology

Therefore, the curative effect on massive bleeding and arterial bleeding is relatively poor, which directly affects the clinical use of adrenochrome hydrazone tablets.

[0003] At the same time, because adrenal hydrazone contains salicylic acid, it will produce a salicylic acid-like reaction after oral administration, that is, it is more irritating to the stomach, which also affects its clinical use.

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