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Anti-newcastle disease virus Chinese medicinal composition and preparation method thereof

A technology of chicken Newcastle disease virus and composition, which is applied in the field of natural green traditional Chinese medicine composition and its preparation, can solve the problems of economic loss in chicken farming, pollution of surrounding environment, and effect of virus on curative effect, and achieve prevention and treatment of animal diseases and clean ecological environment , Immunity-enhancing effect

Inactive Publication Date: 2010-08-18
HENAN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccination is mainly used to prevent the occurrence of the disease, and the prevalence of typical Newcastle disease has been basically controlled. However, factors such as virus mutation, wild virus infection, improper storage or use of vaccines, interference from other diseases on antibodies, etc. will cause immune insufficiency or Failure, resulting in frequent occurrence of atypical Newcastle disease, seriously affecting egg production, increasing production costs, polluting the surrounding environment and causing a vicious circle, causing huge economic losses to the chicken industry
The main therapeutic drugs for Newcastle disease are the chemotherapeutic drugs amantadine hydrochloride and ribavirin. Animal experiments have shown that both drugs have teratogenic effects, and amantadine hydrochloride can also induce the generation of drug-resistant strains. Virus develops drug resistance and affects efficacy

Method used

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  • Anti-newcastle disease virus Chinese medicinal composition and preparation method thereof
  • Anti-newcastle disease virus Chinese medicinal composition and preparation method thereof
  • Anti-newcastle disease virus Chinese medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a. Take 4 parts of Huoxiang by weight, use supercritical extraction technology to extract volatile oil, and dissolve it in ethanol with a volume ratio of 1:3 for subsequent use;

[0022] b. Combine the Huoxiang medicinal residues that have extracted the volatile oil in step a with 5 parts of Radix Isatidis, 25 parts of Honeysuckle, 20 parts of Imperata Rhizoma Imperatae, 10 parts of Poria, 15 parts of Dan Cortex, and 7 parts of Guanzhong. , 5 parts of Scutellaria baicalensis, 6 parts of Sophora flavescens, and 3 parts of Bupleurum chinensis are extracted with water. First soak for 1-2 hours, then extract by hot reflux for 5-8 hours, then filter, take the filtrate and concentrate it on a rotary evaporator to 1 / 100 of the original extract to form a liquid extract;

[0023] c. Carry out 2 times of alcohol precipitation on the medicinal dregs extracted by water, first add 3-5 times the volume ratio of ethanol with 70% ethanol to the residue for alcohol precipitation for 12-...

Embodiment 2

[0026] a, take 6 parts of Huoxiang according to the ratio of parts by weight, adopt supercritical extraction technology to extract volatile oil, and dissolve it with ethanol with a ratio of parts by volume of 1:3 for subsequent use;

[0027] b. Combine the Huoxiang medicinal residues from which the volatile oil has been extracted in step a with 25 parts of Radix Isatidis, 20 parts of Bupleurum Radix, 20 parts of Scutellaria baicalensis, 8 parts of Dan Cortex, 5 parts of Honeysuckle, and 5 parts of Guanzhong. , 4 parts of Rhizoma Imperatae, 3 parts of Poria cocos, and 4 parts of Sophora flavescens are extracted in water together. First, soak for 1-2 hours. The filtrate is concentrated to 1 / 100 of the original extract to form a liquid extract;

[0028] c. Carry out 2 times of alcohol precipitation on the medicinal dregs extracted by water, first add 3-5 times the volume ratio of ethanol with 70% ethanol to the residue for alcohol precipitation for 12-15h, and then add 3-5 times ...

Embodiment 3

[0031] a, take 12 parts of Huoxiang by weight, adopt supercritical extraction technology to extract volatile oil, and dissolve it in ethanol with a volume ratio of 1:3 for subsequent use;

[0032] b. Combine the Huoxiang medicinal residues that have been extracted to get the volatile oil in step a with 10 parts of Radix Isatidis, 15 parts of Guanzhong, 19 parts of Poria cocos, 12 parts of Scutellaria baicalensis, 12 parts of Sophora flavescens, and 5 parts of paeonol. , 5 parts of honeysuckle, 5 parts of Rhizoma Imperatae, and 5 parts of Bupleurum are extracted with water, and the amount of water can be submerged by the raw materials. First soak for 1-2 hours, then extract by hot reflux for 5-8 hours, then filter, and concentrate the filtrate to 1 / 100 of the original extract to form a liquid extract;

[0033] c. Carry out 2 times of alcohol precipitation on the medicinal dregs extracted by water, first add 3-5 times the volume ratio of ethanol with 70% ethanol to the residue f...

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Abstract

The invention discloses an anti-newcastle disease virus Chinese medicinal composition and a preparation method thereof and is characterized in that the Chinese medicinal composition comprises the following raw materials in part by weight: indigowoad root 5-25, honeysuckle 5-25, radix bupleuri 3-20, cyrtomium fortunei 5-15, cogongrass rhizome 4-20, scutellaria baicalensis 5-20, Cortex moutan 5-15, Agastache rugosus 4-12, Poria cocos 3-19 and Radix sophorae flavescentis 4-12. The Chinese medicinal composition can effectively prevent and treat animal diseases, purify ecological environment and provide a natural green ecological product for better serve human health and livestock breeding industry. The Chinese medicinal composition has great advantages of resisting diseases and improving immunity.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine preparation, in particular to a natural green traditional Chinese medicine composition and a preparation method thereof. The composition has obvious inhibitory and killing effects on Newcastle disease virus, can regulate body immunity, and improve overall disease resistance. Background technique [0002] Newcastle disease is caused by Newcastle disease virus and mainly infects poultry as an acute, highly contagious, severe infectious disease. It is one of the major diseases threatening the poultry industry in the world and is listed as Class A infectious disease. At present, vaccination is mainly used to prevent the occurrence of the disease, and the prevalence of typical Newcastle disease has been basically controlled. However, factors such as virus mutation, wild virus infection, improper storage or use of vaccines, interference from other diseases on antibodies, etc. will cause imm...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/12
Inventor 崔斓斓张慧茹刘来亭范根成齐仁立贺秀媛
Owner HENAN UNIVERSITY OF TECHNOLOGY
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