Buccal tablets taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and preparation method thereof

Abstract

The invention relates to buccal tablets taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof, and aims to provide a new preparation, namely salbutamol sulfate and ambroxol hydrochloride buccal tablets, for the vast number of patients and medical workers. The preparation has quick response, can improve the bioavailability of medicaments, give full play to the treatment effects of the medicaments and reduce adverse reactions, is convenient for children to swallow and for old people to take with reduced dosage, and is convenient to carry, store and transport. The preparation method is simple and suitable for mass production. In the method, the buccal tablets are prepared by adding some specific types of auxiliary materials in certain proportions into the salbutamol sulfate and ambroxol hydrochloride serving as the active ingredients according to the conventional technique of pharmaceutical engineering.

Description

technical field A buccal tablet with salbutamol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof. The invention relates to a novel pharmaceutical preparation, in particular to buccal tablets of albuterol sulfate and ambroxol hydrochloride for respiratory diseases and a preparation method thereof. Background technique Respiratory system disease is a common and frequently-occurring disease that endangers people's health, and its incidence rate accounts for the first among many diseases in any age group. According to data from the Statistical Yearbook of the United States, among all causes of death, the cause of death related to respiratory diseases (excluding tumors) rose from the 10th in 1970 to the 4th in 1991 (chronic obstructive pulmonary disease). and No. 8 (pneumonia, influenza and upper respiratory tract infection). The British Society for Thoracic Surgery pointed out in a recent research report that respiratory diseases h...

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Pharmacokinetic studies have proved that it metabolizes rapidly in the

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