Method for preparing amino acid schiff base metal complexes without solvent

Abstract

The invention discloses a method for preparing amino acid schiff base metal complexes without solvent, and relates to a method for preparing the amino acid-Schiff base metal complexes. The invention solves the problems of high solvent consumption and long reaction time in the conventional method for preparing the amino acid schiff base metal complexes. The method comprises the following steps of: 1, under the anhydrous condition, mixing L-amino acid, ortho-hydroxy-benzaldehyde and potassium hydroxide, and grinding for 2 to 5 minutes to obtain amino acid schiff base; and 2, adding bivalent copper salt or bivalent zinc salt into the amino acid schiff base obtained in the step 1, and grinding for 3 to 6 minutes to obtain the amino acid schiff base metal complexes, wherein the step 1 and the step 2 are all completed at room temperature. The whole preparation process needs only 5 to 11 minutes, the reaction time is short, the solvent is not needed, the process is simple, the work efficiency is high, the posttreatment is simple and the yield reaches 80 to 95 percent.

Description

technical field The invention relates to a preparation method of an amino acid Schiff base metal complex. Background technique Amino acid Schiff bases have good complexing ability with metal ions because of the imino (-CH=N-) and carboxyl (-COO-) functional groups in their molecules. These amino acid metal complexes are used as Lewis acids With special biological functions and catalytic effects, it has become one of the research hotspots in organic chemistry and new drug development in recent years. In the medical field, amino acid Schiff base metal complexes can interact with the side chain bases of DNA and have a strong scavenging effect on superoxide free radicals, thus making them useful in anti-tumor, anti-cancer, bacteriostatic, and bactericidal, etc. Exhibits unique medicinal effects; in the field of organic chemistry, amino acid Schiff base metal complexes are used in various organic reactions such as asymmetric cyclopropanation, asymmetric Michael addition, asymmet...

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Problems solved by technology

The purpose of the present invention is to solve the problem that the existing method for preparing amino acid Schiff base metal complex requires a large amount of solvent and long reaction time. The present invention provides a solvent-free method for preparing amino acid Schiff base metal complex Methods

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