Prasugrel compound and new preparation method thereof

Abstract

The invention provides a prasugrel compound and a new preparation method thereof. The new preparation method comprises the following steps: carrying out hydrolysis reaction on a prasugrel crude product to obtain a prasugrel precursor intermediate, adding activated carbon for adsorbing and purifying, and then, carrying out esterification reaction under the catalysis of strong acid salt catalysts to obtain the high-purity prasugrel. The invention has the advantages of simple reaction steps, high yield, low cost and high product purity.

Description

technical field The invention relates to a prasugrel compound and a new preparation method thereof, belonging to the technical field of medicine. Background technique Cardiovascular disease is on the rise year by year, and it is one of the serious diseases that cause human disability and death. The emergence of adenosine diphosphate receptor inhibitors is an important milestone in antiplatelet therapy, which can reduce the risk of cardiovascular events in high-risk patients, prevent sudden distal vascular obstruction in patients undergoing percutaneous coronary intervention, and significantly reduce myocardial infarction, Incidence and mortality of stroke, pulmonary or venous thrombosis. Following ticlopamide and clopidogrel, a new generation of platelet adenosine diphosphate receptor blocker, prasugrel, jointly developed by Sankyo Company of Japan and Eli Lilly Company of the United States, can inhibit platelet aggregation more quickly and effectively. A thienopyridine, ...

AI Technical Summary

Problems solved by technology

This route is relatively simple, the yield is too low, the cost is too high, and the product purity obtained is relatively poor

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