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Application of rhizoma nardostachyos in preparing medicine for preventing and treating osteoporosis

A technology for osteoporosis and nard pine, applied in drug combinations, bone diseases, medical formulas, etc., can solve problems such as regulating the role of minerals in the body

Inactive Publication Date: 2010-09-15
HEERXUN DONGGUAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Chinese Invention Patent Publication No. CN1568965A discloses "a drug for treating osteoporosis and its preparation method", which is mainly made of soybean total flavonoids and epimedium total flavonoids. The drug has estrogen-like effects and kidney-tonifying and bone-strengthening effects Achieving a therapeutic effect, but not mentioning the regulation of mineral action in the body

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  • Application of rhizoma nardostachyos in preparing medicine for preventing and treating osteoporosis
  • Application of rhizoma nardostachyos in preparing medicine for preventing and treating osteoporosis

Examples

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experiment example 1

[0011] 1 Experimental method

[0012] 50 3-month-old male SD rats were randomly divided into 5 groups, namely control group, model group, high-dose group, middle-dose group, and low-dose group. 10 in each group. Rats in the other four groups except the control group were subcutaneously injected with methylprednisolone 3.5 mg / kg, once a day for 60 consecutive days. Administration group gives medicine of the present invention by intragastric gavage simultaneously, and Gansong water decoction adopts conventional water decoction method to prepare, and is concentrated into corresponding concentration, and water decoction different dose groups comprise low dose group (10g / kg), middle dose group (20g / kg). ), the high-dose group (40g / kg); each group of medication was administered by intragastric administration, and all the other groups were administered by oral administration of an equal amount of normal saline, and the experiment was continuously administered for 60 days. After 60 ...

experiment example 2

[0019] 1 Experimental method

[0020] 50 3-month-old male SD rats were randomly divided into 5 groups, namely control group, model group, high-dose group, middle-dose group, and low-dose group. 10 in each group. Rats in the other four groups except the control group were subcutaneously injected with methylprednisolone 3.5 mg / kg, once a day for 60 consecutive days.

[0021] The drug administration group was given the co-decoction water extract of the medicine of the present invention and Epimedium Herba, Salvia Miltiorrhiza and Pueraria Radix by intragastric gavage at the same time. The decoction was prepared by conventional decoction method and concentrated into corresponding concentrations. The different dosage groups of decoction included low-dose group (15g / kg), middle dose group (30g / kg), high dose group (60g / kg); each group of medication was administered by intragastric administration, and all the other groups were administered with equal amount of normal saline, and the...

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Abstract

The invention discloses new application of rhizoma nardostachyos in preparing a medicine for preventing and treating osteoporosis. Rhizoma nardostachyos has no toxic or side effects and can be prepared into any forms of orally taken medicines singly or together with other medicines having prevention and treatment functions by conventional preparation methods, wherein other medicines having functions of preventing and treating osteoporosis comprise one or more then one of herba epimedii, the root of red-rooted salvia and the root of kudzu vine. The invention is suitable for patients with osteoporosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for preventing and treating osteoporosis, belonging to the field of traditional Chinese medicines. technical background [0002] Osteoporosis is a common bone metabolic disease in the elderly. Currently, the age tends to be advanced, and it has become one of the international public health problems. Its pathogenesis has not been very clear, and it is generally believed that it is caused by hormone regulation (estrogen, parathyroid hormone, calcitonin, and active vitamin D), nutritional status (calcium, phosphorus, protein, fat, etc.), physical factors (exercise) , sunlight), immune function and genetic changes are closely related. It shows abnormal endocrine metabolism of the human body, decreased bone mass, destruction of bone microstructure, decreased bone biomechanical properties, and diseases of bone internal quality and quantity. The onset site of osteoporosis is the axial bone of the human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/296A61K36/48A61K36/537A61P19/10
Inventor 曾昭利
Owner HEERXUN DONGGUAN BIOTECH