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Isothermal titration microcalorimeter apparatus and method of use

A titration and isothermal technology, applied in measuring devices, measuring heat, sampling devices, etc., can solve problems such as limiting instrument sensitivity

Active Publication Date: 2010-10-06
MALVERN INSTRUMENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This requires a smaller sample chamber and shorter chamber tubing, which in turn results in a smaller distance between the chamber sensor and the motor and magnetic coupling (a source of electrical noise), which limits the sensitivity of the instrument

Method used

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  • Isothermal titration microcalorimeter apparatus and method of use
  • Isothermal titration microcalorimeter apparatus and method of use
  • Isothermal titration microcalorimeter apparatus and method of use

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Embodiment Construction

[0022] figure 2 One embodiment of an ITC system 200 according to the invention is shown schematically. The ITC system 200 includes a microcalorimeter 210 and an automated pipette assembly 220 . The microcalorimeter 210 includes a reference chamber 240 and a sample chamber 250 designed to be substantially identical in terms of heat capacity and volume. Chambers 240 and 250 are constructed of a suitable chemically inert and thermally conductive material, such as gold, platinum, tantalum, hastelloy, and the like. Chambers 240 and 250 can be of essentially any suitable shape, but need to be of the same shape so that a fully symmetrical arrangement can be provided and effective mixing of the titrant with the sample can be achieved. In the disclosed embodiment, the chambers 240 and 250 are rectangular in cross-section, and the cross-section in the transverse horizontal direction may be circular, resulting in a coin-shaped chamber with circular facing surfaces.

[0023] In order ...

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Abstract

An automatic pipette assembly for an isothermal titration micro calorimetry system, comprising a pipette housing, a syringe with a titration needle arranged to be inserted into a sample cell for supplying titrant, and a linear activator for driving a plunger in the syringe, the titration needle is rotatable with respect to the housing and is provided with a stirring paddle arranged to stir fluid in the sample cell, wherein the automatic pipette assembly comprises a stirring motor for driving the rotation of the titration needle. There is also provided an isothermal titration micro calorimetry system.

Description

[0001] Cross References to Related Patents [0002] This application claims priority to US Provisional Patent Application No. 60 / 984432, filed November 1, 2007; the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates generally to a microcalorimeter, and more particularly to features that improve the performance of microcalorimeters, especially isothermal titration calorimeters. Background technique [0004] Microcalorimeters are widely used in biochemistry, pharmacology, cell biology, and other fields. Calorimetry provides a direct method for measuring changes in the thermodynamic properties of biological macromolecules. A microcalorimeter is generally a two-chamber instrument in which the properties of a diluted solution of a test substance in buffer in a sample chamber are continuously compared to an equal amount of buffer in a reference chamber. Measured differences between properties such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N25/20
CPCG01N1/14G01N25/20G01K17/006G01N25/4866G01N2035/1058G01N35/109
Inventor V·V·普洛特尼科夫A·罗查尔斯基
Owner MALVERN INSTRUMENTS
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