Preparation method of enramycin premix

The technology of enramycin and premix is ​​applied in the field of preparation of enramycin premix, which can solve the problems of high energy consumption, high production cost, complicated process and the like in spray drying, so as to reduce the cost of treatment in the later stage and reduce the production cost. Cost reduction and less environmental pollution

Active Publication Date: 2010-10-20
濮阳泓天威药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are two main production processes for the existing enramycin premix: ① extract the crude product from the enramycin fermentation broth with hydrochloric acid and methanol solution, etc., and then refine it with a macroporous adsorption resin to obtain enramycin Vegetarian crude drug, then add rice bran oil and corn flour and mix uniformly to obtain enramycin premix (see quality standards for imported veterinary drugs). This method uses a large amount of organic solvent and acid-base (resin regeneration) in the enramycin purification production process etc.), complex process, high energy consumption and production cost, and relatively large pollution to the environment; ②The enramycin fermentation liquid is subjected to plate and frame filtration, and part of the fermentation liquid filtrate is removed, and then spray-dried, and the dried product is diluted with a carrier, Mix to obtain powdered enramycin premix, the spray-dried fermented liquid still contains about 90% moisture, the energy consumption of spray-drying is high, and the production cost is high

Method used

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  • Preparation method of enramycin premix

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Embodiment 1 A kind of preparation method of enramycin premix comprises the following steps:

[0025] Fermentation broth preparation Insert the enramycin-producing bacteria into the seed tank, grow for 40-48 hours, connect it to the fermenter at an inoculation rate of 10%, pass air according to the volume ratio of fermentation broth: air = 1: 0.8-1, and ferment The temperature is controlled at 28-30°C, the stirring speed is 120-140 rpm, water is replenished during the fermentation process, and the concentration of the substrate is kept stable, and the culture is carried out for 9-10 days, so that the content of enramycin in each liter of fermentation broth reaches 2-6g; 1000L of ramycin fermented liquid was filtered with a membrane filter press, the pressing pressure was 1.0-1.2MPa, the quality of the filter cake was 200kg, and flash drying was adopted, the inlet air temperature was 160-180°C, and the outlet air temperature was 70-80°C to obtain 35.6 kg dried product, p...

Embodiment 2

[0026] Embodiment 2 A kind of preparation method of enramycin premix comprises the following steps:

[0027] The preparation of the fermentation broth was the same as in Example 1. 1000L of enramycin fermentation broth was filtered by a diaphragm filter press, the maximum pressing pressure was controlled at 1.6-2.0MPa, the water content of the filtered filter cake was 70%, and the number of filter cakes was 180kg. It was dried with a high-efficiency fluidized bed, and the air inlet temperature was 120-200 130° C., the air outlet temperature is 37-70° C., 35 kg of dry product is obtained, crushed, mixed with 7 kg of rice bran powder, and 40.4 kg of 8% powdery enramycin premix is ​​obtained. See Table 1 for the process parameters and quality indicators.

Embodiment 3

[0028] Embodiment 3 A kind of preparation method of enramycin premix comprises the following steps:

[0029] The preparation of the fermentation broth was the same as in Example 1. Squeeze 1000L of enramycin fermentation broth with flexible pressing equipment, control the maximum pressing pressure of 3-5MPa, filter the cake with a water content of 40%, and the number of filter cakes is 90kg, crush it, and use flash drying, and the air inlet temperature is 160-180°C , the air outlet temperature was 60-70° C., and the dried product was pulverized to obtain 34.5 kg of dried product, which was mixed with 48.5 kg of rice bran powder to obtain 80 kg of 4% powdery enramycin premix. See Table 1 for the process parameters and quality indicators.

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Abstract

The invention relates to a preparation method of an enramycin premix, comprising the following steps of: carrying out high-pressure filtration/squeeze on enramycin fermentation liquor prepared by using a conventional method; separating the fermentation liquor; then carrying flash drying on an obtained enramycin filter cake and then crushing; adding a powdery carrier to fine mycelium powder according to the purity and the end-product requirement content of a dried product so as to regulate the concentration of the fine mycelium powder; evenly mixing to obtain a powdery enramycin premix; and pelleting the powdery enramycin premix into a granulated enramycin premix according to demands. The preparation process of the preparation method does not need to refine and extract enramycin, does not consume organic solvents and acid and base, and has less pollution on the environment, and the production cost is largely reduced; the content and the uniformity of the obtained product meet the quality standard requirements of imported veterinary drugs, and the stability of the product meets the specified requirements; moreover, dangerous solid wastes, such as antibiotic bacterium residues and the like, are not generated in the production and preparation process, thereby greatly reducing the pollution to the environment and the later-period management cost.

Description

technical field [0001] The invention relates to the field of feed medicine additive manufacturing, in particular to a preparation method of enramycin premix. Background technique [0002] Enramycin is also known as anlemycin, enramycin, persistent mycin, enduracidin, enradin. Molecular formula Enramycin A: C 107 h 138 N 26 o 31 C 12 ; Enramycin B: C 108 h 140 N 26 o 31 C 12 . It is fermented by actinomyces (Streptomyces fungicidicus NO.B5477). It is a polypeptide antibiotic combined with unsaturated fatty acids and more than a dozen amino acids. The main components are enramycin A and B, which are in the form of hydrochloride application. Enramycin hydrochloride is white or slightly yellowish white powder (the crude product is gray or taupe powder with special odor), decomposes at 234-238°C, easily soluble in dilute hydrochloric acid, slightly soluble in water, methanol, Ethanol, insoluble in acetone. The drug was developed by Takeda Pharmaceutical Co., Ltd. in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/14A61K9/16A23K1/17C12P21/04A61P31/04A61P1/14C12R1/04A23K20/195
Inventor 张永旺黄振锋郭燕军王新红赵军飞张道伟周超刘远生尤敏孙春领
Owner 濮阳泓天威药业有限公司
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