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Pyrazole compound and preparation method thereof

A compound and pyrazole technology, applied in the field of pyrazole heterocyclic compounds, can solve the problems of difficult purification, many steps and the like

Inactive Publication Date: 2011-11-09
ARMY MEDICAL UNIV +1
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  • Abstract
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Problems solved by technology

However, in the existing artificially synthesized pyrazole heterocyclic compounds, it is determined by their different structural features: most of the synthetic reactions have many steps and are not easy to purify

Method used

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  • Pyrazole compound and preparation method thereof
  • Pyrazole compound and preparation method thereof
  • Pyrazole compound and preparation method thereof

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Embodiment Construction

[0020] (1) A pyrazole compound, on the pyrazole ring of the pyrazole compound, there is a (2-ethoxycarbonyl-2-cyanoethenyl) amino group, and there are two general formulas of I and II respectively: :

[0021]

[0022] In the two general formulas Ⅰ and Ⅱ, R is selected from -COOCH 3 ,-COOCH 2 CH 3 ,-H.

[0023] (2) A preparation method of pyrazole compounds, the compound prepared by the method is the pyrazole compound of specific embodiment (1), which consists of aminopyrazole derivatives, ethyl cyanoacetate and triethyl orthoformate It is prepared from raw materials, among which, aminopyrazole derivatives have the following two general formulas III and IV:

[0024]

[0025] In the two general formulas Ⅲ and Ⅳ, R is selected -COOCH 3 ,-COOCH 2 CH 3 ,-H;

[0026] The method comprises the steps of:

[0027] 1. dissolving aminopyrazole derivatives with anhydrous acetonitrile; wherein, anhydrous acetonitrile: aminopyrazole derivatives=40 milliliters: 0.05 moles;

[...

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Abstract

The invention discloses a pyrazole compound and a preparation method thereof. The compound is a pyrazole heterocyclic compound a pyrazole ring of which is connected with (2-ethoxycarbonyl-2-cyanoethylene) amino. The preparation method comprises the following steps of: taking amino pyrazole derivative, ethyl cyanoacetate and triethyl orthoformate as raw materials, dissolving the amino pyrazole derivative into anhydrous acetonitrile and mixing the solution uniformly, then adding the ethyl cyanoacetate and the triethyl orthoformate into the solution in turn, and obtaining a high-purity product through the operations of heating reflux polymerization, cooling crystallization, filter and crystal collection, crystal washing with anhydrous ethanol and the like. The pyrazole compound has pesticidal activity and is suitable to be used as pesticide. The preparation method has the advantages of few synthetic reaction step, simple purification method, simple and convenient experimental operation and high product purity.

Description

technical field [0001] The present invention relates to pyrazole heterocyclic compounds. Background technique [0002] Studies have shown that many natural compounds with physiological and pharmacological activities contain pyrazole heterocyclic structural units. Pyrazole heterocyclic compounds do have strong physiological and pharmacological activities such as antibacterial, antispasmodic, anti-inflammatory, regulating plant growth, and anti-platelet aggregation, and can be widely used in plant protection agents such as weeding, insecticide, fungicide, and acaricide, as well as thermal agents. and photosensitive recording materials. Therefore, the research on pyrazole heterocyclic compounds and their artificial synthesis is of great significance. However, in the existing artificially synthesized pyrazole heterocyclic compounds, it is determined by their different structural features: most of the synthesis reactions have many steps and are not easy to purify. Contents of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D231/38A01N43/56A01P7/04
Inventor 周小霞刘作华陶长元杜军沈海宁肖翠翠郑习霞李艳范兴孙大贵刘仁龙左赵宏
Owner ARMY MEDICAL UNIV
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