Chinese medicinal effervescence medicament and preparation method thereof

A technology for effervescent agent and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine effervescent agent and its preparation, and achieves the effects of fast absorption, improved hygroscopicity and simple preparation process

Active Publication Date: 2010-12-01
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is already authorized patent about the preparation method of Chinese medicine effervescent tablet, but there is no report about the present invention

Method used

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  • Chinese medicinal effervescence medicament and preparation method thereof
  • Chinese medicinal effervescence medicament and preparation method thereof
  • Chinese medicinal effervescence medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Get the following prescription raw materials (in grams) for subsequent use:

[0054] Honeysuckle 3750g Scutellaria baicalensis 3750g Forsythia 7500g

[0055] The preparation method comprises the following process steps:

[0056] (1) The above three flavors, scutellaria baicalensis slices, add 10 times the amount of water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, let it cool, centrifuge, and concentrate the supernatant to a relative density of 1.10- 1.15 (70-80°C) clear paste, let cool, centrifuge, add 2mol / L hydrochloric acid solution to the supernatant at 80°C to adjust the pH value to 1.0-2.0, keep warm for 1 hour, let stand for 12 hours, centrifuge, and precipitate Add 6-8 times the amount of water, adjust the pH value to 7.0 with 40% sodium hydroxide solution, add the same amount of ethanol, stir to dissolve, centrifuge, and adjust the pH value to 2.0 with 2mol / L hydrochloric acid solution...

Embodiment 2

[0058] The preparation of the Chinese medicine extract is the same as in Example 1, and the gained extract is ground into fine powder. According to the ratio of medicated powder: citric acid: tartaric acid: sodium bicarbonate=5: 2.1: 1.9: 4.3 for the composition of the effervescent tablet, add citric acid, Tartaric acid, sodium bicarbonate, appropriate amount of mannitol, 0.7% blueberry essence and 0.9% aspartame, mix well, according to sucrose stearate S-15: simethicone: absolute ethanol = 2:1:72 It is the ratio of the binder, wherein the binder consumption can account for 5-20% (V / W) of the total weight of the medicated powder and solid auxiliary materials, granulate, dry, granulate, add 0.5% magnesium stearate, and mix well , pressed into 1000 pieces, that is.

Embodiment 3

[0060] The preparation of the Chinese medicine extract is the same as in Example 1, and the gained extract is pulverized into fine powder, and according to the ratio of medicated powder: citric acid: sodium bicarbonate=7: 1.5: 1.5 for effervescent tablets, add citric acid, sodium bicarbonate, 7% sucrose stearate S-15, 8% xylitol fatty acid ester, appropriate amount of mannitol, 0.5% blueberry flavor, mix well, dry press granules, dry, granulate, add 0.3% polyethylene glycol, Mix well, press into 1000 pieces, that is.

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PUM

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Abstract

The invention relates to a Chinese medicinal effervescence medicament and a preparation method thereof, and belongs to the field of Chinese medicaments. The Chinese medicinal effervescence medicament is prepared from at least two different surfactants or emulsifiers, preferably sugar ester, polyoxyethylene sorbitol aliphatic ester, glyceryl monostearate, glycerin fatty acid ester, middle carbon-chain fatty glyceride, phospholipid, polyglycerin ester and the like, wherein one emulsifier can be substituted by pharmaceutically acceptable edible dimethyl silicon oil or hydrogenated soybean oil orother edible oil such as peanut oil, olive oil and the like. After the substances are added, the common production process for the Chinese medicinal effervescence medicament is greatly improved so that the production process is easy to operate, the quality stability of the medicament is improved and the preparation inspection index is greatly improved compared with the past.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and more specifically relates to a traditional Chinese medicine effervescent medicament and a preparation method thereof. Background technique [0002] Effervescent tablet refers to a tablet containing edible alkali and organic acid, which can produce gas when it meets water and is effervescent. According to the route of administration, it can be divided into oral effervescent tablets, oral effervescent tablets, and external effervescent tablets. Although its preparation method has been mastered by some western pharmacy researchers decades ago, there is no real medicinal effervescent tablet listed in foreign countries until the early 1970s. This is because effervescent tablets have special requirements for processing technology and processing conditions. [0003] Effervescent tablets have a long history of development in foreign countries, and are widely recognized by the pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/46A61K47/12A61K47/14A61K47/24A61K47/34A61K47/36A61K47/40A61K47/44A61K36/19A61K36/315A61K36/634A61K36/708A61K36/71A61K36/736A61K36/8964A61K36/8968A61K36/899A61K36/9066A61K33/06A61K35/32A61K47/26
Inventor 张保献张卫华
Owner BEIJING INCREASEPHARM CORP LTD
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