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Method for detecting compound salvia miltiorrhiza tablet

A technology for compound Danshen tablet and detection method, which is applied to measurement devices, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2010-12-08
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the above-mentioned identification method, there are the following disadvantages: first, the developer used contains the highly toxic chemical substance benzene, which is very harmful to the testing personnel; A On the corresponding position of the chromatogram of the reference substance, the colors of the spots are obviously inconsistent, indicating that the detection method cannot accurately detect tanshinone II in the test substance. A

Method used

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  • Method for detecting compound salvia miltiorrhiza tablet
  • Method for detecting compound salvia miltiorrhiza tablet
  • Method for detecting compound salvia miltiorrhiza tablet

Examples

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Effect test

Embodiment 1

[0042] According to the specification requirements of a Compound Danshen Tablet in the Pharmacopoeia of the People's Republic of China in 2010, 2 batches of specifications (1) (5 tablets in each batch, respectively numbered 6 and 7), 2 batches of specifications (3) (5 tablets in each batch) , respectively numbered 8, 9), 1 batch of specifications (2) (2 pieces, numbered 10).

[0043] Grind the above 2 batches of specifications (1) 5 tablets per batch, 2 batches of specifications (2) 5 tablets per batch and 1 batch of specifications (3) 2 tablets with sugar coating removed, add 10ml of ether each, ultrasonicate for 5 minutes, filter After that, discard the filter residue, evaporate the filtrate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the test solution respectively (the corresponding numbers are 6, 7, 8, 9, 10). Take another dihydrotanshinone Ⅰ reference substance (number 1), cryptotanshinone reference substance (number 2), tanshinone Ⅰ ref...

Embodiment 2

[0045] According to the specification requirements of a Compound Danshen Tablet in the Pharmacopoeia of the People's Republic of China in 2010, 2 batches of specifications (1) (5 tablets in each batch, respectively numbered 6 and 7), 2 batches of specifications (3) (5 tablets in each batch) , respectively numbered 8, 9), 1 batch of specifications (2) (2 pieces, numbered 10).

[0046] Grind the above 2 batches of specifications (1) 5 tablets per batch, 2 batches of specifications (2) 5 tablets per batch and 1 batch of specifications (3) 2 tablets with sugar coating removed, add 10ml of ether each, ultrasonicate for 5 minutes, filter After that, discard the filter residue, evaporate the filtrate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the test solution respectively (the corresponding numbers are 6, 7, 8, 9, 10). Take another dihydrotanshinone Ⅰ reference substance (number 1), cryptotanshinone reference substance (number 2), tanshinone Ⅰ ref...

Embodiment 3

[0048] According to the specification requirements of a Compound Danshen Tablet in the Pharmacopoeia of the People's Republic of China in 2010, 2 batches of specifications (1) (5 tablets in each batch, respectively numbered 6 and 7), 2 batches of specifications (3) (5 tablets in each batch) , respectively numbered 8, 9), 1 batch of specifications (2) (2 pieces, numbered 10).

[0049] Grind the above 2 batches of specifications (1) 5 tablets per batch, 2 batches of specifications (2) 5 tablets per batch and 1 batch of specifications (3) 2 tablets with sugar coating removed, add 10ml of ether each, ultrasonicate for 5 minutes, filter After that, discard the filter residue, evaporate the filtrate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the test solution respectively (the corresponding numbers are 6, 7, 8, 9, 10). Take another dihydrotanshinone Ⅰ reference substance (number 1), cryptotanshinone reference substance (number 2), tanshinone Ⅰ ref...

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Abstract

The invention provides a method for detecting a compound salvia miltiorrhiza tablet, which comprises the following steps of: providing a test sample solution of a compound salvia miltiorrhiza tablet to be detected; selecting one of dihydrotanshinone I, cryptotanshinone, tanshinone I, tanshinone IIA and borneol for dissolving in ethyl acetate to be used as a contrast sample solution; and detecting the test sample solution by using a mixture of petroleum ether and acetone as a developing solvent through adopting a thin-layer chromatography. In the invention, the mixture of the petroleum ether and the acetone is used as the developing solvent; compared with the benzene-contained developing solvent used in the prior art, the developing solvent used by the invention has no poison; and in addition, a detecting result indicates that the developing solvent used by the invention can accurately detect active components of the compound salvia miltiorrhiza tablet.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a detection method for compound danshen tablets. Background technique [0002] Compound Danshen Tablets is a traditional Chinese medicine preparation made from Danshen, Panax notoginseng, and borneol as raw materials and excipients. Compound Danshen tablets are generally divided into three specifications, among which specification (1) is film-coated small pieces, each weighing 0.32g, which is equivalent to 0.6g of decoction pieces; specification (2) is film-coated large pieces, each weighing 0.8g, which is equivalent to decoction pieces 1.8g; specification (3) is sugar-coated tablets, equivalent to 0.6g decoction pieces. [0003] The quality standards of Compound Danshen Tablets are recorded on page 904 of the 2010 edition of the Pharmacopoeia of the People's Republic of China. Among them, the identification method of Compound Danshen Tablets includes: take 5 tablets of this produ...

Claims

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Application Information

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IPC IPC(8): A61K36/537G01N30/90A61P9/10A61K31/045
Inventor 吴笛王德勤李楚源
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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