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Spina date seed depression-resolving and nerve-soothing composition and preparation method thereof

A technology of Jujube Seed and Yu Anshen, which is applied in the direction of medical formulas, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of saponins sedative and hypnotic effects, etc., achieves no toxic side effects, simple preparation method, and reduces The effect of dosage

Active Publication Date: 2012-01-25
TIANJIN MEDICAL UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, chemical studies have shown that jujube seed contains saponins, flavonoids, and alkaloids. Although it has been reported in the literature that saponins and flavonoids have sedative and hypnotic effects, some studies have questioned the sedative and hypnotic effects of saponins

Method used

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  • Spina date seed depression-resolving and nerve-soothing composition and preparation method thereof
  • Spina date seed depression-resolving and nerve-soothing composition and preparation method thereof
  • Spina date seed depression-resolving and nerve-soothing composition and preparation method thereof

Examples

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Embodiment

[0028] The treatment methods of the medicinal materials in Examples 1-8 are the same, except for the difference in the weight ratio of the effective parts of the three kinds of jujube seeds. As shown in Table 1, the medicinal materials treatment methods are as follows:

[0029] a. The jujube seed is crushed, passed through a 40-mesh sieve, and defatted with petroleum ether. Add 8 mass times the volume percentage of 70% ethanol aqueous solution, heat and reflux for extraction 2 times, each 2 hours, filter, and combine the extracts After the filtrate is concentrated in ethanol until it has no alcohol taste, it is dissolved with 4 times the amount of water, adjusted to pH 5 with 18% HCl, and extracted with n-butanol 5 times to obtain n-butanol liquid 1 and acid water liquid.

[0030] b. The acid water solution is first extracted with n-butanol 5 times to obtain n-butanol solution 2. Then the acid water solution is added with ammonia to adjust the pH to 12, extracted with 3 times the a...

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Abstract

The invention discloses a spina date seed depression-resolving and nerve-soothing composition and a preparation method thereof. The composition comprises 16 to 200 weight parts of spina date seed total saponins, 4 to 30 weight parts of spina date seed total alkaloids, and 0 to 50 weight parts of spina date seed total flavonoids. The composition is separated and purified by an acid-alkali and solution extraction method according to the polarity and alkalinity or acidity of each part of spina date seed, and has a simple preparation method and moderate product price. The three effective parts ofthe spina date seed cannot be separated simultaneously by the conventional preparation process. Compared with the prior art, the composition prepared by combining each effective part of the spina date seed has depression-resolving and nerve-soothing pharmacological activity exceeding that of a spina date seed medicinal material; and a further prepared preparation can reduce dosage and enhance thecompliance of medicaments and does not have any toxic or side effect.

Description

Technical field [0001] The invention relates to a jujube seed composition with the effects of relieving depression and tranquilizing the nerves, treating insomnia and depression, and a preparation method thereof, and belongs to the field of traditional Chinese medicine. Background technique [0002] Insomnia is one of the most common sleep disorders; depression is a common affective mental disorder, a syndrome characterized by significant and lasting depression. Traditional Chinese medicine in my country believes that insomnia is insomnia; depression is a "stagnation syndrome", and both insomnia and depression syndromes belong to the category of emotional diseases, which are caused by emotional stimulation leading to imbalance of yin and yang, qi and blood in the body, dysfunction of viscera, and even mind. Loss of nutrition or restlessness is an important factor in human disease. Traditional Chinese medicine mostly starts with regulating the liver, nourishing blood and calming t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704
Inventor 乔卫段宏泉周晶李陆刘婧姝符敬伟杨奕
Owner TIANJIN MEDICAL UNIV