Fluorescent multi-parameter endoscopic measuring method and system

A measurement method and measurement system technology, which are applied in the field of fluorescence multi-parameter endoscopy measurement methods and systems, can solve the problems of slow fluorescence multi-parameter endoscopy measurement speed and low efficiency, and achieve the effects of high speed, small damage and short time.

Inactive Publication Date: 2011-01-05
SHENZHEN UNIV
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Problems solved by technology

[0004] The purpose of the embodiments of the present invention is to provide a fluorescent multi-parameter endoscopic measurement method, which aims to solve the problems of slow speed and low efficiency of the existing fluorescent multi-parameter endoscopic measurement

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  • Fluorescent multi-parameter endoscopic measuring method and system
  • Fluorescent multi-parameter endoscopic measuring method and system
  • Fluorescent multi-parameter endoscopic measuring method and system

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Embodiment Construction

[0027] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0028] In the embodiment of the present invention, the excitation light is divided into multiple sub-beams corresponding to multiple sub-regions of the sample, and the multiple sub-beams are transmitted into the living body, and each sub-beam is focused on the sample with fluorescent substances to form multi-point excitation fluorescence. Fluorescence derivation, two-dimensional scanning of the sample by multiple sub-beams, so as to obtain the fluorescence lifetime information of the spectral resolution of different positions of the entire sample, the speed is fast, the time is short, and the damage...

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Abstract

The invention is suitable for the field of photoelectric detection and provides a fluorescent multi-parameter endoscopic measuring method and a fluorescent multi-parameter endoscopic measuring system. The fluorescent multi-parameter endoscopic measuring method comprises the following steps of: generating exciting light; dividing the exciting light into a plurality of sub-light beams corresponding to a plurality of sub-regions of a sample, wherein fluorescent substances are uniformly distributed in the sample; adjusting the plurality of sub-light beams so as to conduct the plurality of sub-light beams into an organism and focusing the plurality of sub-light beams on the sample; scanning the sample by using the plurality of sub-light beams so as to allow the fluorescent substances in each sub-region to emit fluorescent light; acquiring the fluorescent light in real time; and distinguishing multi-parameter information of the fluorescent light. Two-dimensional scanning is performed on thesample by using the plurality of sub-light beams, so that the fluorescent lifetime information, which is distinguished through spectra at different positions, of the entire sample is acquired. The method and the system have the advantages of high speed, short time, small damage to the organism, and contribution to biomedical researches and have great significance for early diagnosis of cancers.

Description

technical field [0001] The invention belongs to the field of photoelectric detection, in particular to a fluorescent multi-parameter endoscopic measurement method and system. Background technique [0002] Fluorescence microscopy has become an important tool in life sciences, especially cell biology research. Multi-photon excitation fluorescence microscopy has the advantages of small killing effect on living organisms, large penetration depth, and chromatographic ability, and has become an important means of life science research. In addition to the distribution of fluorescence intensity and the structure information of the change response sample, the fluorescence spectrum and fluorescence lifetime both contain rich functional information of biological systems. Since the fluorescence emission wavelength is related to the energy level structure of the fluorophore, the measurement of the fluorescence spectrum can distinguish the molecular species of the sample or identify diff...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B1/00A61B5/00
Inventor 邵永红屈军乐牛憨笨
Owner SHENZHEN UNIV
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