Method for preparing 2,2-dimethyl cysteamine salts
A technology of dimethylcysteamine salt and tetramethylthiazolidine, which is applied in the field of preparation 2, can solve the problems of harsh operating conditions, long process flow, and low yield
Inactive Publication Date: 2011-01-12
赵云现
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Problems solved by technology
[0003] The currently used synthetic method uses nitromethane, acetone, benzyl mercaptan and lithium aluminum hydride as raw materials. The disadvantages are long process flow, harsh operating conditions, harsh operating environment and low yield.
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[0020] Add 1 mole of 2,2,5,5-tetramethylthiazolidine and concentrated hydrochloric acid (37%) according to the molar ratio shown in the following table into a 500ml reaction flask, heat to boiling, and feed water vapor Distill until no oil drops appear in the receiving fraction, the distillation time is about 20-25 hours, and the reaction solution is concentrated to dryness by distillation under reduced pressure. Then, a mixed solvent of ethanol and ethyl acetate was added for crystallization to obtain white crystals with a melting point of 218-222°C.
[0021]
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The invention relates to a method for preparing 2,2-dimethyl cysteamine salts. The method comprises the following step of: performing hydrolysis reaction on 2,2,5,5-tetramethyl thiazolidine in the presence of acid to obtain corresponding 2,2-dimethyl cysteamine salts. The method has the advantages of simple process operation, high product purity and high yield, and is suitable for industrialized production.
Description
technical field [0001] The invention relates to a method for preparing 2,2-dimethylcysteamine salt. Background technique [0002] 2,2-Dimethylcysteamine salt, especially its hydrochloride is an important intermediate for synthetic medicine and veterinary medicine. [0003] The currently used synthetic method uses nitromethane, acetone, benzyl mercaptan and lithium aluminum hydride as raw materials, and has the disadvantages of long process flow, harsh operating conditions, harsh operating environment, and low yield. [0004] For this reason, we conducted in-depth research and developed a method for preparing 2,2-dimethylcysteamine salt. The method is simple to operate, has a good operating environment and a high yield, and is suitable for industrial production. Contents of the invention [0005] The object of the present invention is to provide a method for preparing 2,2-dimethylcysteamine salt, which is simple to operate, has a good operating environment and high yield, ...
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Inventor 赵云现
Owner 赵云现