Compound common andrographis herb injection for treating high fever of pigs and preparation method thereof

A technology for compound andrographis paniculata and injection, which is applied in the directions of medical preparations, antipyretics, and pharmaceutical formulations containing active ingredients, can solve the problems that diseases cannot be well controlled, pathogens cannot be accurately determined, and treatment time is not timely, etc. To achieve the effect of reducing the drug resistance of pathogenic microorganisms, enhancing the function of phagocytic cells, and reducing the number of drugs

Inactive Publication Date: 2011-02-09
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the widespread occurrence of such diseases recently, the etiology cannot be accurately determined, and the pathogens are diverse and complicated, the disease progresses rapidly, and the mortality rate is extremely high. General conventional methods and simple treatment with drugs are often adopted, which basically cannot be cured. Even after the disease is determined, Due to the inconvenience caused by the combination and matching of drugs to the majority of farmers, the disease cannot be well controlled, and the treatment time is not timely and it is easy to cause great losses.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Take 25L of water for injection, add Andrographis paniculata extract 3kg, stir to dissolve, then add anhydrous sodium bisulfite 0.2kg, ammonium chloride bethanecholine 0.05kg, EDTA-2Na0.01kg, stir until all dissolve.

[0021] (2) Get 30L of water for injection, add 0.5kg of hydrochloric acid, after stirring evenly, add ofloxacin 4.5kg, after stirring and dissolving, add 1.5kg of gentamicin sulfate, stir and dissolve;

[0022] (3) Take Tween-801kg in a water bath and heat to 60°C, and mix well with 0.5kg of zedoary oil.

[0023] (4) Combine the prepared solution of step (1) and step (2), after stirring evenly, add Sulpyrine 30kg, after stirring and dissolving, mix evenly with the solution obtained from step (3), add water for injection to 100L, stir evenly, keep for 15-20min, adjust the pH value to 5.00-7.00 with 40% sodium hydroxide solution by mass percent concentration or 10% volume percent hydrochloric acid solution, and prepare it for use after the liquid is cl...

Embodiment 2

[0025] (1) Take 25L of water for injection, add Andrographis paniculata extract 7kg, stir to dissolve, then add anhydrous sodium bisulfite 0.2kg, ammonium chloride bethanecholine 0.05kg, EDTA-2Na0.01kg, stir until all dissolve.

[0026] (2) Get 30L of water for injection, add 0.5kg of hydrochloric acid, after stirring evenly, add ofloxacin 1.5kg, after stirring and dissolving, then add gentamicin sulfate 6kg, stir and dissolve;

[0027] (3) Take Tween-801kg in a water bath to 60°C, mix well with zedoary oil 1.5kg.

[0028] (4) Combine the solution prepared by step (1) and step (2), add and stir evenly, then add 8 kg of Sulpyrine, stir and dissolve, mix evenly with the solution obtained by step (3), add injection Water to 100L, stir evenly, keep for 15-20min, adjust the pH value to 5.00-7.00 with 40% sodium hydroxide solution by mass percent concentration or 10% volume percent hydrochloric acid solution, and prepare it after the liquid medicine becomes clear Compound Androgra...

Embodiment 3

[0030] (1) Take 25L of water for injection, add Andrographis paniculata extract 4kg, stir to dissolve, then add anhydrous sodium bisulfite 0.2kg, ammonium chloride bethanecholine 0.05kg, EDTA-2Na0.01kg, stir until all dissolve;

[0031] (2) Get 30L of water for injection, add 0.5kg of hydrochloric acid, after stirring evenly, add ofloxacin 4kg, after stirring and dissolving, then add gentamicin sulfate 2kg, stir and dissolve;

[0032] (3) Take Tween-801kg in a water bath to 60°C, mix well with zedoary oil 1.5kg.

[0033] (4) Combine the solutions obtained in steps (1) and (2), add and stir evenly, then add 25 kg of Sulpyrine, stir and dissolve, mix evenly with the solution obtained in step (3), add injection Water to 100L, stir evenly, keep for 15-20min, adjust the pH value to 5.00-7.00 with 40% sodium hydroxide solution by mass percent concentration or 10% volume percent hydrochloric acid solution, and prepare it after the liquid medicine becomes clear Compound Andrographis...

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PUM

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Abstract

The invention discloses a compound common andrographis herb injection for treating high fever of pigs and a preparation method thereof. The invention aims to provide the compound common andrographis herb injection and the preparation method thereof, wherein the compound common andrographis herb injection can treat the high fever caused by pig bacteria and virus composite infection, has quick treatment response, can treat both principal and secondary aspects of diseases, reduces taking frequency and is convenient to take; and the preparation method has a simple process and is easy to implement. Each 100L of injection comprises 3 to 7 kg of common andrographis herb extractum, 0.5 to 1.5kg of zedoary oil, 1 to 6kg of gentamycin sulfate, 1.5 to 4.5kg of ofloxacin, 8 to 30kg of analgin, 0.05kg of ammonium chloride bethanechol, 0.2kg of anhydrous sodium bisulfite, 0.01kg of EDTA-2Na, 1kg of Tween-80, 0.5kg of hydrochloric acid, and the balance of water for injection. The injection has the effect in many aspects at the same time by the reasonable proportion of a plurality of medicaments, has quick response to treat the high fever caused by the pig bacteria and the virus composite infection, is directly applied without diagnosis and can achieve the treatment effect of a plurality of medicaments when used at one time.

Description

technical field [0001] The invention relates to a compound Andrographis paniculata injection for treating hyperthermia in pigs and a preparation method thereof. Background technique [0002] Pig hyperthermia is a relatively serious disease of pigs, which is mainly caused by the combined infection of bacteria and viruses. Sick pigs have high fever, loss of appetite, redness, blueness, cyanosis of the skin and ear tips, and sometimes necrotic foci, spots, feces Dryness, constipation, listlessness, some have diarrhea or diarrhea and constipation alternately, the mortality rate is very high, autopsy shows multiple organ damage, swelling, or edge necrosis, massive swelling and bleeding of lymph nodes. [0003] Due to the widespread occurrence of such diseases recently, the etiology cannot be accurately determined, and the pathogens are diverse and complicated, the disease progresses rapidly, and the mortality rate is extremely high. General conventional methods and simple treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/4152A61K31/7036A61P29/00A61K9/08A61K31/5383A61K31/27
Inventor 徐克福
Owner TIANJIN SHENGJI GRP CO LTD
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