Unlock instant, AI-driven research and patent intelligence for your innovation.

Eye in-situ gel

An in situ gel, ophthalmic technology, applied in medical preparations containing active ingredients, peptide/protein components, nervous system diseases, etc., can solve the problem of ophthalmic in situ gel without nerve growth factor, etc.

Active Publication Date: 2012-01-04
STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But there is no ophthalmic in situ gel containing nerve growth factor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Eye in-situ gel
  • Eye in-situ gel
  • Eye in-situ gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The proportioning ratio of this embodiment is shown in the following table:

[0061] NGF

200μg / ml

Poloxamer 407

214mg / ml

Poloxamer 188

96mg / ml

Benzyl alcohol

9mg / ml

acetate buffer

Adjust to pH5.5

Water for Injection

Appropriate amount

[0062] Preparation method: Stir in an ice bath, add poloxamer to water for injection, store at low temperature until the poloxamer is completely dissolved, dissolve NGF and benzyl alcohol in pH5.5 acetate buffer, sterilize and filter, add to In the above polymer solution, add water for injection to a sufficient amount, stir evenly, and aseptically pack.

[0063] The appropriate amount of water for injection means that the amount of water used is to adjust the parameters of the above components to the parameters shown in the table. This is easily accomplished by those skilled in the art.

[0064] Poloxamer 407 and Poloxamer 188 were produced by BASF, Germany. ...

Embodiment 2

[0066] The proportioning ratio of this embodiment is shown in the following table:

[0067] NGF

[0068] Preparation method: Stir in an ice bath, add poloxamer to water for injection, store at low temperature until the poloxamer is completely dissolved, and dissolve NGF, alanine, glycine, arginine, and benzyl alcohol in pH6.5 phosphate buffer first After sterilizing and filtering, add to the above-mentioned polymer solution, add water for injection to a sufficient amount, stir evenly, and aseptically dispense.

Embodiment 3

[0070] The proportioning ratio of this embodiment is shown in the following table:

[0071] NGF

[0072] Preparation method: Stir in an ice bath, add poloxamer to water for injection, store at low temperature until the poloxamer is completely dissolved, dissolve chitosan in an appropriate amount of dilute acetic acid, dissolve NGF and benzyl alcohol in pH5.5 acetate buffer , after sterilizing and filtering, mix the above solutions, add water for injection to a sufficient amount, stir evenly, and aseptically dispense.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an eye in-situ gel composition. The eye in-situ gel composition contains 50 to 400 mu g / ml nerve growth factor, 1 to 20 mg / ml stabilizer, 5 to 400 mg / ml thermosensitive gel and water; and the pH value of the eye in-situ gel composition is between 4.5 and 7.5. In the invention, by adopting the components and mixing ratio and controlling the pH value of the in-situ gel composition in a certain range, the eye in-situ gel preparation containing the nerve growth factor is prepared. The preparation can be stored at normal temperature; and being liquid, the preparation becomes stable semi-solid gel when entering eyes.

Description

technical field [0001] The invention relates to an ophthalmic in-situ gel composition. Background technique [0002] Excimer laser in situ keratomileusis (LASIK) is currently the mainstream procedure in corneal refractive surgery due to its advantages of mild postoperative reaction, high safety and good predictability. However, within 6 months after surgery, almost 50% of the cases experienced symptoms of dry eye, and some patients had discomfort such as foreign body sensation, which affected the satisfaction of patients with the surgery to varying degrees. Studies have found that the emergence of these symptoms and signs is related to the corneal nerves being damaged to varying degrees during the operation during the operation to cut the corneal flap and cut the corneal stroma. Drug research on promoting the repair of corneal nerve injury is a current research hotspot. [0003] Nerve Growth Factor (NGF) is the earliest neurotrophic factor discovered and the most thoroughl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K38/18A61P25/00A61P27/02
Inventor 谭剑平蒋立新潘铁成周志文
Owner STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com