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Pirfenidone-contained gel composition

A technology of pirfenidone and a composition, applied in the field of external gel preparations, can solve problems such as failure to prevent recurrence, and achieve the effects of good patient tolerance, definite curative effect and good stability

Inactive Publication Date: 2011-02-16
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no satisfactory treatment for this disease at present, and most of them can only achieve short-term curative effect, but cannot prevent recurrence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Pirfenidone 30 parts

[0016] Carbomer 50 servings

[0017] Propylene glycol 10 parts

[0018] Azone 2 parts

[0019] Tween 50 servings

[0020] 10 parts triethanolamine

[0021] Appropriate amount of purified water

[0022] Sodium metabisulfite 0.5 parts

[0023] Makes 1000 servings

[0024] Preparation process: 1. Configuration of carbomer gel Disperse carbomer with appropriate amount of purified water, soak and swell, adjust pH to about 6.0 with triethanolamine solution, and obtain transparent carbomer gel. Add the azone solution dissolved in propylene glycol and stir well. Add the solution of sodium metabisulfite and stir well.

[0025] 2. Preparation of drug solution Pirfenidone was ground with Tween to obtain a transparent solution.

[0026] 3. Mix 1 and 2, stir evenly, add the full amount of purified water, continue stirring evenly, and get a gel.

Embodiment 2

[0028] Pirfenidone 15 parts

[0029] Carbomer 50 servings

[0030] Glycerin 10 parts

[0031] Azone 2 parts

[0032] Tween 50 servings

[0033] 10 parts triethanolamine

[0034] Appropriate amount of purified water

[0035] Sodium metabisulfite 0.5 parts

[0036] Makes 1000 servings

[0037] According to the above prescription, the same preparation process as in Example 1 was used to obtain a gel.

Embodiment 3

[0039] Pirfenidone 10 parts

[0040] Carbomer 50 servings

[0041] Propylene glycol 10 parts

[0042] Azone 2 parts

[0043] transcutol-p 50 servings

[0044] 10 parts triethanolamine

[0045] Appropriate amount of purified water

[0046] Sodium metabisulfite 0.5 parts

[0047] Makes 1000 servings

[0048] According to the above prescription, the same preparation process as in Example 1 was used to obtain a gel.

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PUM

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Abstract

The invention provides a pirfenidone-contained gel composition and a preparation method thereof. The pirfenidone-contained gel composition comprises pirfenidone and other pharmaceutically acceptable accessories. The invention further illuminates the clinical use method and the applications of the preparation mode.

Description

technical field [0001] The invention relates to a gel preparation containing pirfenidone and some pharmaceutically acceptable auxiliary materials. The invention also relates to the use of such gel formulations for external use. Background technique [0002] Psoriasis (Psoriasis) is commonly called as psoriasis. Motherland medicine calls psoriasis "white boils", which is a common chronic, recurrent, and inflammatory skin disease, characterized by papules and erythema of various sizes, covered with silvery white scales on the surface, with clear borders, and prone to hair loss. On the scalp, the extensor sides of the limbs and the back, there are more men than women. It is easy to recur or aggravate in spring and winter, and it is more relieved in summer and autumn. The pathological changes of psoriasis vulgaris are epidermal hyperkeratosis and parakeratosis. Small abscesses composed of neutrophils can be seen in the parakeratotic area, called Munro's small abscesses. The ...

Claims

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Application Information

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IPC IPC(8): A61P17/12A61K31/4418A61K9/06A61P17/06
Inventor 李晓红
Owner BEIJING TRADE STAR MEDICAL TECH
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