Veterinary doxycycline hydrochloride injection and preparation method thereof

A technology of doxycycline hydrochloride and injection, which is applied in the field of preparation of the injection, can solve the problems of short duration of drug effect, difficult preservation of the drug, difficulty in absorption by livestock and poultry, etc., to avoid stress and many inconveniences, inhibit Bacterial reproduction, effect of lowering temperature

Active Publication Date: 2011-02-16
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the current doxycycline hydrochloride is not easy to be absorbed by livestock and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The doxycycline hydrochloride injection of this embodiment, taking 100ml as an example, its preparation method is as follows: take 10mL water, add sodium bisulfite 1g, dissolve completely, add calcium oxide 2g, cosolvent vitamin C or ammonium chloride 3g Dissolve completely, then add 30g of any ratio of PEG-200 and glycerin formal, stir evenly, add 20g of sodium sulfate and TMP with a mass ratio of 1:1, dissolve completely, then add 20g of doxycycline hydrochloride, stir evenly, Heat to 50°C, slowly add 8g of triethanolamine to dissolve and complex doxycycline hydrochloride, cool to room temperature, adjust the pH value at 4.5-6.5, add water for injection to 100ml, and filter with a 0.22-0.45μm organic filter membrane, Subpackaging, potting, and sterilization at 105°C for 30 minutes.

Embodiment 2

[0016] The doxycycline hydrochloride injection of this embodiment, taking 100ml as an example, its preparation method is as follows: take 15mL of water, add 0.5g of sodium bisulfite, dissolve completely, add calcium lactate 3g, cosolvent vitamin C or ammonium chloride 2g dissolved, then add 50g of α-pyrrolidone and propylene glycol with a mass ratio of 3:2, stir evenly, add a total of 30g of sodium sulfate and TMP with a mass ratio of 1:2, dissolve completely, then add 30g of doxycycline hydrochloride, and stir Evenly, heat to 60°C, slowly add 8g of triethanolamine to dissolve and complex doxycycline hydrochloride, cool to room temperature, adjust the pH value at 4.5-6.5, add water for injection to 100ml, and use a 0.22-0.45μm organic filter membrane Filter, pack, pot, and sterilize at 105°C for 30 minutes.

Embodiment 3

[0018] The doxycycline hydrochloride injection of this embodiment, taking 100ml as an example, its preparation method is as follows: take 10mL of water, add 1g of sodium formaldehyde sulfoxylate, dissolve completely, add magnesium sulfate 1g, cosolvent vitamin c or chloride Ammonium 2g, dissolve completely, then add 40g of α-pyrrolidone and glycerin formal with a mass ratio of 1:1, stir evenly, add a total of 10g of sodium sulfate and trimethoprim with a mass ratio of 1:1 to dissolve, and then Add 10g of doxycycline hydrochloride, stir evenly, heat to 55°C, slowly add 8g of triethanolamine to dissolve and complex doxycycline hydrochloride, cool to room temperature, adjust the pH value to 4.5-6.5, add water for injection to 100ml, Filter through a 0.22-0.45 μm organic filter membrane, subpackage, pot, and sterilize at 105°C for 30 minutes.

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Abstract

The invention discloses a veterinary doxycycline hydrochloride injection and a preparation method thereof. 100 ml of injection mainly comprises the following components by weight: 10 to 30 g of doxycycline hydrochloride, 1 to 3 g of complexant, 1 to 5 g of cosolvent, 0.5 to 1 g of antioxidant, 10 to 30 g of antibacterial synergist, 30 to 60 g of organic solvent, 5 to 10 g of triethanolamine and the balance of water for injection. In the veterinary doxycycline hydrochloride injection of the invention, methoxybenzylaminopyrimidine compounds and sodium sulfate or sodium sulfite serving as synergists are adopted to be combined with the doxycycline hydrochloride so as to improve the complexation degree of the doxycycline hydrochloride and the complexant, reduce the temperature of complex reaction, and improve the stability of the doxycycline hydrochloride; and the methoxybenzylaminopyrimidine adopted by the invention is a synergist, can extend the maintenance time of effective blood concentration, improve pharmacodynamic action time, and avoid stress and inconvenience due to repeated medicament administration by a veterinarian.

Description

technical field [0001] The invention relates to a veterinary doxycycline hydrochloride injection and a preparation method of the injection. Background technique [0002] With the continuous development of large-scale and intensive breeding of livestock and poultry, the current respiratory diseases and complications of livestock and poultry seriously threaten the development of the breeding industry. Doxycycline hydrochloride, also known as doxycycline, deoxyoxytetracycline hydrochloride. The antibacterial spectrum is similar to that of oxytetracycline, and the antibacterial activity in vivo and in vitro is stronger than that of oxytetracycline and tetracycline. It is mainly used for the treatment of livestock and poultry mycoplasma disease, colibacillosis, salmonellosis, pasteurellosis, brucellosis, anthrax, spirochete, etc. . But the current doxycycline hydrochloride is not easy to be absorbed by livestock and poultry, the drug effect duration is shorter, and the medicine...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K33/04A61P31/04A61K31/505A61K31/65
Inventor 吴红云班曼曼李建正
Owner 河南后羿制药有限公司
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