Oleanolic acid piperazine salt and preparation method thereof

Abstract

The invention discloses an oleanolic acid piperazine salt and a preparation method thereof. The oleanolic acid salt refers to oleanolic acid piperazine salt and has the chemical structure general formula described in the specification of the invention. The oleanolic acid piperazine salt has the advantages of good solubility, dissolving rate, low moisture absorption, high stability and higher bioavailability. Therefore, the invention provides a form of oleanolic acid salt with bright clinical practice prospect.

Description

technical field The invention belongs to the field of chemical synthesis, in particular to a piperazine oleanolic acid salt and a preparation method thereof. Background technique Clinically, oleanolic acid is used for adjuvant treatment of acute and chronic hepatitis. It has a certain protective effect on liver injury, can reduce the elevated serum alanine aminotransferase, promote liver cell regeneration, and accelerate the repair of necrotic tissue. Modern pharmacological studies have shown that oleanolic acid still has the effects of lowering fat, lowering blood sugar, anti-tumor, and two-way regulation of immunity. At present, the development and utilization of oleanolic acid other than liver protection are still rare, and its clinical preparations mainly include tablets and capsules. In terms of physical and chemical properties, oleanolic acid is an alkane-type pentacyclic triterpenoid compound, and its powder is white and crystalline, odorless, tasteless, and insolu...

AI Technical Summary

Problems solved by technology

Therefore, the technical problem to be solved in the present invention is to provide a kind of oleanolic acid for existing oleanolic acid with poor water solubility and low bioavailability, or the defect of strong hygroscopicity and instability of oleanolic acid salt. An acid salt and a preparation method thereof, the oleanate has high solubility, low hygroscopicity, high physical and chemical stability, and has excellent clinical application prospects

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