2 results about "Piperazine salt" patented technology

The present invention provides a flame retardant composition which has an excellent flame retardancy and water resistance, a flame-retardant resin composition, a molded article, and a molded product thereof. The present invention provides a flame retardant composition characterized by containing the following component (A), component (B) and component (C). In the flame retardant composition, the component (A) is one or more melamine salts selected from the group consisting of melamine orthophosphate, melamine pyrophosphate and melamine polyphosphate; the component (B) is one or more piperazine salts selected from the group consisting of piperazine orthophosphate, piperazine pyrophosphate and piperazine polyphosphate; and the component (C) is an epoxy compound having a molecular weight or a number average molecular weight of from 300 to 10,000.

The application discloses arylpiperazine salt compounds, a synthesis method thereof and application thereof in antidepressants, and belongs to the field of medicinal chemistry. The arylpiperazine salt compounds containing bioactivity are obtained through a plurality of continuous reactions such as N-alkylation, protection of a group, condensation and deprotection, etc. of arylpiperazine as raw material. Researches show that the compounds exhibit high receptor binding of 5-HT 2A R and GABA A Rs. The target points are confirmed through molecular docking, micro-thermal mobility instrument, surface plasmon resonance, inositol-phosphoric acid (IP1) accumulation and cell membrane patch clamp, etc.; and the anti-inflammatory activity of the compounds is evaluated by enzyme-linked immunosorbent assay, so as to provide a potential active structure skeleton for development of antidepressants.