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Amitraz transdermal agent and preparation method thereof

An amidine transdermal agent, the technology of amitraz, which is applied in the field of veterinary medicine, can solve the problems of damaged fur quality, affecting human health, weight loss, etc., and achieves the effect of low administration frequency, avoiding liver first-pass effect, and convenient medication

Inactive Publication Date: 2011-04-06
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ectoparasites that dogs and cats are susceptible to mainly include lice, fleas, acariasis, etc. On the one hand, they can directly infect dogs and cats, causing skin inflammation, weight loss and damage to the quality of fur; on the other hand, many spider insects It can act as a disseminator of some infectious and parasitic diseases, leading to the occurrence of insect-borne diseases, thus affecting human health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The amitraz transdermal agent of this embodiment is composed of the following components in parts by weight: 0.6 parts of amitraz, 4,500 parts of N,N-dimethylglycine menthyl ester, 200 parts of borneol, and 35,000 parts of 95% ethanol . Its preparation method is to add 0.6 parts of amitraz to 35,000 parts of 95% ethanol, heat to 55°C, stir slowly to dissolve, add 200 parts of borneol, 4500 parts of N,N-dimethylglycine menthyl ester, and stir well be made of.

Embodiment 2

[0012] The amitraz transdermal agent of this embodiment is composed of the following components in parts by weight: 0.8 parts of amitraz, 6,000 parts of N,N-dimethylglycine menthyl ester, 500 parts of borneol, and 70,000 parts of 95% ethanol . Its preparation method is to add 0.8 parts of amitraz to 70,000 parts of 95% ethanol, heat to 70°C, stir slowly to dissolve, add 500 parts of borneol, 6000 parts of N,N-dimethylglycine menthyl ester, and stir well be made of.

Embodiment 3

[0014] The amitraz transdermal agent of this embodiment is composed of the following components in parts by weight: 1 part of amitraz, 3000 parts of N,N-dimethylglycine menthyl ester, 300 parts of borneol, and 50000 parts of 95% ethanol . Its preparation method is to add 1 part of amitraz to 50,000 parts of 95% ethanol, heat to 40 ° C, stir slowly to dissolve, add 300 parts of borneol, 3000 parts of N,N-dimethylglycine menthyl ester, and stir well be made of.

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PUM

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Abstract

The invention discloses an amitraz transdermal agent and a preparation method thereof. The amitraz transdermal agent comprises the following components in part by weight: 0.5 to 1 part of amitraz, 100 to 500 parts of borneol, 300 to 6,000 parts of N,N-dimethyl menthol glycinate and 35,000 to 70,000 parts of over 95 percent ethanol. In the amitraz transdermal agent of the invention, N,N-dimethyl menthol glycinate, borneol and the like are used as auxiliary materials, wherein the N,N-dimethyl menthol glycinate is a biodegradable derivative of menthol and can be used in medicines and cosmetics such as cream, ointment and linimentum for promoting the transdermal absorption of the medicines by skin and increasing medicinal effect; in addition, the borneol has penetration promoting and physically cooling functions. In the amitraz transdermal agent of the invention, the ethanol is added to increase the solubility of the amitraz and the activity of the amitraz in the transdermal agent for promoting skin penetration, and the ethanol proper has a synergetic penetration promoting effect.

Description

technical field [0001] The invention relates to an amitraz transdermal agent and a preparation method of the amitraz transdermal agent, belonging to the technical field of veterinary medicine. Background technique [0002] Dogs and cats have always been two animals that have been in frequent contact with humans. With the continuous improvement of human living standards, their status as companion animals is also rising. Therefore, the health of dogs and cats is also related to human health and well-being. Life, ectoparasitic diseases are one of the main factors affecting the health of dogs and cats. The ectoparasites that dogs and cats are susceptible to mainly include lice, fleas, and acariosis. On the one hand, they can directly infect dogs and cats, causing skin inflammation, weight loss, and damage to the quality of fur; on the other hand, many spider insects It can act as a disseminator of some infectious and parasitic diseases, leading to the occurrence of insect-borne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/155A61K47/18A61K47/10A61P33/14
Inventor 吴红云李建正王丽景
Owner ZHENGZHOU HOUYI PHARMA