Intravenous self-administration jugular intubator and animal model construction method by using same

A technology of self-administration and jugular vein, which is applied in catheters, medical science, veterinary instruments, etc., can solve the problems of lack of domestic agents, restrictions on catheter application, and large trauma in rats, and achieve shortened operation time and convenient manufacturing , The effect of low manufacturing cost

Inactive Publication Date: 2011-04-27
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has disadvantages such as troublesome operation, complex equipment, and relatively large trauma to rats.
The jugular vein catheterization without back piece is widely used because of its simple operation, simple equipment and less tr

Method used

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  • Intravenous self-administration jugular intubator and animal model construction method by using same
  • Intravenous self-administration jugular intubator and animal model construction method by using same
  • Intravenous self-administration jugular intubator and animal model construction method by using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1, such as Figure 1 to Figure 4 As shown, the jugular vein catheter for intravenous self-administration in this embodiment includes a gasket 1, a rigid catheter 4, a connector 3, an adhesive block 2 and a hose, and the gasket 1 is made of circular plastic polypropylene with a mesh The hole, the rigid conduit 4 is bent in an L shape, has a vertical portion 41 and a horizontal portion 42, the connector 3 is located in the middle of the vertical portion 41, and has an external thread, and the bonding block 2 connects the connector 3 and the rigid conduit 4 Bonded to the end surface of the gasket 1, the vertical portion 41 is arranged vertically to the gasket 1, and the hose includes a first hose 5 and a second hose 6 connected to the first hose 5, and the first hose 5 The inner diameter of the inner diameter of the vertical portion 41 and the inner diameter of the second flexible pipe 6 are all adapted. The rigid catheter 4 is also equipped with a catheter cap 7 ...

Embodiment 2

[0058] Experimental animals and feeding environment: 20 clean-grade male Sprague-Dawley rats, provided by Zhejiang Experimental Animal Center (Experimental Animal Production License Number: SCXK (Zhejiang) 2008-0033), weighing 250g-300g. Animals were kept in separate cages in a well-ventilated animal room with a circadian rhythm of 12 / 12h (8am-8pm). The ambient temperature is controlled at 22°C-24°C, and the humidity is 40%-70%. The handling of animals during the experiment complied with the standards of the "Guiding Opinions on the Kindness of Experimental Animals" promulgated by the Ministry of Science and Technology of the People's Republic of China in 2006 [14].

[0059] Surgical instruments (Roboz): ophthalmic scissors, tissue scissors, toothed tweezers, toothless tweezers, scalpel handle, hemostatic forceps, 4-0 atraumatic suture needle, 3-0 atraumatic suture thread. See Figure 6 and Figure 7 As shown, the guide tube 8 has a handle portion 81 and a pointed barb port...

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Abstract

The invention relates to an intravenous self-administration jugular intubator which is characterized by comprising a gasket, a hard catheter, a connecting head, a bonding block and a hose, wherein the hard catheter is bent in an L shape and comprises a vertical part and a horizontal part; the connecting head is arranged in the middle of the vertical part; the bonding block is used for bonding the connecting head and the hard catheter on the end surface of the gasket; the vertical part is perpendicular to the gasket; and one end of the hose is hermetically connected with the horizontal part, and the other end of the hose is a free end. The invention also discloses an animal model construction method by using the intubator. Compared with the prior art, the invention has the advantages that the intravenous self-administration jugular intubator has simple structure and lower manufacturing cost and is convenient to product, manufacture, popularize and apply and easy to obtain materials; by utilizing the intubator, the success ratio of jugular intubatton is increased, the operation time is shortened, the operation technology is easy to master, the experimental success ratio is ensured and the intravenous self-administration jugular intubator conforms to an international principle of 3R (Reduction, Replacement and Refinement).

Description

technical field [0001] The invention relates to a jugular vein cannula for intravenous self-administration, and also relates to a method for constructing an animal model using the cannula. It belongs to the technical field of intravenous self-administration. Background technique [0002] Intravenous self-administration is one of the most widely used animal models in the study of drug addiction. In this model, the animal obtains the drug from the jugular vein by actively pressing the plate or touching the nose, and completes the effective intravenous self-administration behavior. Meanwhile, intravenous self-administration experiments generally last for several weeks or even months. Therefore, the success rate, stability and availability of venous catheterization are more important in whether animals can maintain effective self-administration behavior for a long time. Venous catheterization is the experimental basis to ensure the completion of intravenous self-administratio...

Claims

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Application Information

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IPC IPC(8): A61D7/00A61M25/00A61M25/02A01K67/027
Inventor 刘昱吕秀依张栗赵春马宝苗
Owner NINGBO UNIV
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