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Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof

An amphiphilic copolymer and super-hydrophilic technology, which can be used in drug combinations, diseases, pharmaceutical formulations, etc., and can solve problems such as poor foaming and cleaning performance

Inactive Publication Date: 2011-04-27
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantageously, mild cleansing compositions prepared via the above two methods tend to have relatively poor foaming and cleaning performance

Method used

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  • Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof
  • Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof
  • Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

example

[0395] example

[0396]The following Drop Shape Analysis ("DSA"), Dynamic Light Scattering ("DLS"), Polymer Foam, Formulation Foam, Solution Viscosity, Formulation Flash Foam, and Formulation Viscosity tests were used in the point-of-care test methods and in the Examples below. Specifically, as described above, the DSA test is used to determine to what extent a polymeric material (eg, SAC) in a composition according to the present invention reduces surface tension. The DLS test, Polymer Foam Test and Solution Viscosity can be used to determine whether a particular SAC is suitable to provide reduced irritation and high foaming, and the Formulation Flash Foam Test and Formulation Viscosity Test can be used to determine that a particular composition is capable of producing high foam and and / or provide a degree of beneficial viscosity (which is often desirable for cleaning compositions).

[0397] Unless otherwise specified, the content of each ingredient in the examples and com...

example E1-E6 and comparative example C1-C3

[0421] Examples E1-E6 and Comparative Examples C1-C3: Preparation of polymerized surfactants

[0422] The following polymerized surfactants of Inventive Examples E1-E6 and Comparative Examples C1-C3 were prepared.

[0423] Table 1

[0424]

[0425]

[0426] The preparation of the polymerized surfactant shown in Table 1 is as follows: the hydrolyzed PA-18 in the comparative example C1 is obtained by the following steps: carry out 1-octadecene and maleic anhydride (PA-18 low viscosity low color grade, The reaction of a 1:1 alternating copolymer (commercially available from Chevron Phillips Chemical, LLC) with aqueous sodium hydroxide produces an octadecene / MA copolymer with an average of about 50 amphiphilic repeat units (by weight average based), the mole fraction of the amphiphilic repeating unit is about 100%, and there is a C16 hydrophobic group in the amphiphilic repeating unit.

[0427] The hydrolyzed PA-14 in Comparative Example C2 was obtained by performing t...

example E7-E12 and comparative example C4-C5

[0448] Examples E7-E12 and Comparative Examples C4-C5: Preparation of Simulated Compositions for Dynamic Light Scattering Tests

[0449]The mock compositions of Examples E7 to E12 and Comparative Examples C4 and C5 were prepared for DLS testing. A simulated composition was prepared by separately mixing the specific polymerized surfactant described above with the other ingredients as follows: Water (about 50.0 parts) was added to a beaker equipped with a mechanical stirrer and a hot plate. Sodium methylparaben (and) sodium propylparaben (and) sodium ethylparaben (Nipasept Sodium, Clariant Corp.) powder was then added and stirred until dissolved. Then, the polymerized surfactant was added at a low stirring speed to avoid aeration. Tetrasodium EDTA (Versene XL, Dow Chemical) was added and mixing continued. Provide heating (not to exceed 60° C.) if necessary to obtain a homogeneous solution. If necessary, cool the batch to 25°C while continuing to agitate at medium speed. Ad...

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Abstract

Provided are healthcare compositions comprising a superhydrophilic amphiphilic copolymer and a cosmetically-acceptable or pharmaceutically-acceptable carrier. Also, provided are methods of cleansing or treating the human body by applying healthcare compositions of the present inventions to the body.

Description

technical field [0001] The present invention relates to compositions containing superhydrophilic amphiphilic copolymers, in particular, the present invention relates to compositions containing superhydrophilic amphiphilic copolymers useful in healthcare applications and having relatively low irritation associated therewith combination. Background technique [0002] Synthetic detergents, such as cationic surfactants, anionic surfactants, amphoteric surfactants and nonionic surfactants, are widely used in various detergents and cleaning compositions to impart cleaning performance thereto. Additionally, in certain compositions (e.g., personal care compositions such as shampoos, lotions, etc.), it may be advantageous to use a combination of surfactants sufficient to achieve relatively high lather volume and / or lather stability. and content. [0003] However, as is known in the art, synthetic cleaners tend to be irritating to the skin and eyes. Thus, as the levels of such clea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/81A61Q5/02A61Q19/00A61Q19/10
CPCA61Q19/10A61Q19/005A61Q5/02A61K8/732A61P15/02A61P17/00A61P17/10
Inventor M·J·费沃拉F·C·孙J·J·利布里兹J·B·加德纳R·M·沃尔特斯
Owner JOHNSON & JOHNSON CONSUMER COPANIES
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