Method for preparing fresh motherwort preparation

A technology of fresh motherwort and motherwort, which is applied in the field of preparation of fresh motherwort preparations of traditional Chinese medicine, can solve the problems of heat-sensitive active ingredient damage, product yield reduction, spray-dried powder agglomeration, etc., to ensure stability and uniformity, and improve total biological The effect of alkali content and loose texture

Active Publication Date: 2013-05-08
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, adding dextrin before spray drying will increase the humidity, which will cause agglomeration, and will cause the spray-dried powder content to be unqualified. In addition, this method does not realize the benefits of concentrating fresh motherwort juice within a certain range, and does not Aware of the need for drying, sieving, sizing steps after granulation
[0005] At the same time, the above two methods did not take into account the low content of active ingredients in wild fresh motherwort, which is uncontrollable, and did not take into account the use of modern agricultural technology to cultivate fresh motherwort with high yield, high efficiency and high biological activity.
The spray drying uses the principle of instantaneous heating to dry the extract. Although it is instantaneous heating, in the actual production process, the air inlet temperature of the spray drying equipment is about 200°C, and the outlet air temperature is about 100°C. The temperature is also relatively high, and the spray-dried powder stays in the tower for a long time. Since this product is fed with fresh medicinal materials of Motherwort, the high-temperature environment of the tower body has a certain destructive effect on the heat-sensitive active ingredients of the fresh medicinal materials. The spray drying process is in the production process. It is easy to cause agglomeration and coking of the spray-dried powder, and this part of the powder cannot be put into the next production process, resulting in a great waste of products. The product yield rate is reduced, and a certain amount of dust pollution is produced to the atmosphere

Method used

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  • Method for preparing fresh motherwort preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment one prepares fresh motherwort capsule

[0027] 1. Planting fresh motherwort

[0028] 1.1 Seed selection: Clean the seeds whose purity does not meet the requirements, use a sieve to remove impurities, remove empty, pests, and other disabled seeds and weed seeds, and select full and plump seeds.

[0029] 1.2 Seed treatment: Turn the seeds in the sun for 1 to 2 days before sowing to make the seeds dry uniformly, increase the permeability of the seeds, and improve the vitality; it also has a certain bactericidal effect. Before sowing, mix 35 kg / mu of plant ash into the seeds, and then mix it with decomposed human excrement and urine to make seed ash, which is good for controlling the sowing amount.

[0030] 1.3 Site selection and site preparation: Select sunny, deep soil, humus-rich soil and well-drained sandy soil, which is slightly acidic and meets the secondary standard in "National Soil Environmental Quality GB15618-1995". more than level three. Remove the...

Embodiment 2

[0059] Embodiment 2 Preparation of fresh motherwort tablets (film-coated tablets) (no auxiliary materials added during freeze-drying)

[0060] The basic process is the same as the preparation of fresh motherwort capsules in Example 1, and steps 1 to 6 are the same as above;

[0061] 7. Dry granulation: take fresh motherwort freeze-dried powder, add 1 / 2 prescription amount of microcrystalline cellulose, mix, place in a dry granulator and granulate with a 30-mesh screen, dry granulation parameters: humidity 40% RH~50%RH, host pressure 6~7MPa, host speed 600r / min, feeding voltage 120V, the prepared granules are sieved with a 20-mesh screen to remove coarse particles, and the sieved coarse particles can be re-granulated.

[0062] 8. Drying: Dry the above granules in an oven, control parameters: temperature 75-85°C, time 5 hours.

[0063] 9. Total blending: Add the remaining microcrystalline cellulose, sodium carboxymethyl cellulose and appropriate amount of magnesium stearate (0....

Embodiment 3

[0068] Embodiment three, preparation fresh motherwort sheet (dispersible tablet) (do not add auxiliary material when freeze-drying)

[0069] The basic process is the same as the preparation of fresh motherwort capsules in Example 1, and steps 1 to 6 are the same as above;

[0070] 7. Dry granulation: take fresh motherwort freeze-dried powder, add 1 / 2 prescription amount of microcrystalline cellulose and low-substituted hydroxypropyl cellulose to mix, put it in a dry granulator and use a 30-mesh screen to granulate, dry-process Granule parameters: Humidity 40%RH~50%RH, main engine pressure 6~7MPa, main engine speed 600r / min, feeding voltage 120V, the prepared granules are sieved with 20 mesh to remove coarse particles, and the sieved coarse particles can be processed Granulate again.

[0071] 8. Drying: Dry the above granules in an oven, control parameters: temperature 75-85°C, time 5 hours.

[0072] 9. Total blending: add the remaining microcrystalline cellulose, cross-linke...

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Abstract

The invention discloses a method for preparing a fresh traditional Chinese medicine motherwort preparation, comprising the following steps: artificially cultivating motherwort by modern agriculture technologies instead of wild motherwort to obtain fresh high-quality motherwort with less pesticide and heavy metal residuals and high bioactivity; washing the fresh motherwort, sterilizing the fresh motherwort with ozone water, cutting the fresh motherwort into pieces, and homogenizing the motherwort; collecting juice and sieving to obtain fresh motherwort juice; conveying the fresh motherwort juice to a container; decompressing and concentrating the juice at a temperature of 30-80 DEG C to obtain a concentrated solution of which the relative density is 1.01-1.30g / cm<3>; freezing and drying the concentrated solution to obtain fresh motherwort powder; and taking the fresh motherwort powder to prepare into the fresh motherwort preparation. The method provide by the invention is simple in steps and easy to operate; and the prepared fresh motherwort preparation reaches the standard requirements and has good stability. By using the sterilization technology with the ozone water and the freezing and drying process, the microorganism number in the preparation is greatly reduced and the active ingredients of various heat-sensitive activities are retained maximally; and meanwhile, the product yield is improved and the product cost is reduced.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine fresh motherwort preparation Background technique [0002] Motherwort is recorded on page 204 of the 2005 edition of the "Chinese Pharmacopoeia", which is the aerial part of the Lamiaceae plant Motherwort. It has the effects of promoting blood circulation and regulating menstruation, diuresis and detumescence. It is used to treat irregular menstruation, dysmenorrhea, amenorrhea, etc. [0003] The main chemical components of Motherwort include alkaloids, diterpenoids, flavonoids, various trace elements and fatty acids. Among them, alkaloids are more researched, which are also important ingredients for the treatment of gynecological diseases, including motherwort and stachydrine hydrochloride. Motherwort raw medicinal materials and motherwort preparations are commonly used clinically, and the quality control is based on stachydrine hydrochloride. "Chinese Pharmacopoeia" 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/533A61P15/00
Inventor 王建国
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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