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Method for enriching and purifying arctiin from burdock

A technology for arctiin and burdock is applied in the field of purification of arctiside and arctiin in burdock by using macroporous adsorption resin to enrich and purify burdock, and can solve the problems of low extraction rate and low extraction purity, and achieve high extraction purity and fast adsorption analysis. Also fast, high mechanical strength effect

Inactive Publication Date: 2011-05-25
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying arctiin in burdock with macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method utilizing macroporous adsorption resin to enrich and purify arctiin in burdock, its steps are as follows:

[0027] (1) Pass through a 60-mesh sieve after the dried burdock is crushed, and reflux extraction with 60% ethanol with 5 times the volume of burdock powder for 2 times, each time for 3 hours;

[0028] (2) Suction filtration of the burdock extract treated in step (1), and decompression of the extract to reclaim ethanol to obtain the initial extract;

[0029] (3) The obtained first extract is added into ethyl acetate whose volume is 5 times of the volume of the extract alcohol solution to extract, then adjust its pH value to 2.0 with acid, let stand, suction filter, and reclaim the solvent under reduced pressure to obtain the crude arctiin Extract;

[0030] (4) the gained arctiin crude extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-II type resin produced by Tianj...

Embodiment example 2

[0035] Implementation case 2: a method for enriching and purifying arctiin in burdock using macroporous adsorption resin, the steps are as follows:

[0036] (1) Pass through a 40-mesh sieve after the dried burdock is pulverized, and reflux extract 3 times with 75% ethanol with 8 times the volume of burdock powder, each for 4 hours;

[0037] (2) Suction filtration of the burdock extract treated in step (1), and decompression of the extract to reclaim ethanol to obtain the initial extract;

[0038] (3) Adding the obtained initial extract to ethyl acetate whose volume is 8 times the volume of the extract alcohol solution is extracted, then adjust its pH value to 2.3 with acid, leave standstill, suction filter, and reclaim the solvent under reduced pressure to obtain the crude arctiin Extract;

[0039] (4) the obtained arctiin crude extract is adsorbed with a macroporous adsorption resin, and the macroporous resin used is the D4006 type resin produced by Tianjin Nankai University...

Embodiment example 3

[0044] Implementation case 3: a method for enriching and purifying arctiin in burdock using macroporous adsorption resin, the steps are as follows:

[0045] (1) Pass through an 80-mesh sieve after the dried burdock is pulverized, and reflux extract 3 times with 85% ethanol with 10 times the volume of burdock powder, each time for 4 hours and 6 hours;

[0046] (2) Suction filtration of the burdock extract treated in step (1), and decompression of the extract to reclaim ethanol to obtain the initial extract;

[0047] (3) The obtained initial extract is added into ethyl acetate whose volume is 10 times of the volume of the extract alcohol solution to extract, then adjust its pH value to 2.5 with acid, leave standstill, suction filter, and reclaim the solvent under reduced pressure to obtain the crude arctiin Extract;

[0048] (4) the obtained arctiin crude extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-9 typ...

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PUM

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Abstract

The invention belongs to the field of natural organic chemistry, and particularly relates to a method for enriching and purifying arctiin in burdock by using macroporous adsorbent resin. By using macroporous adsorption technology to separate and purify arctiin, the invention has the characteristics of good adsorption selectivity for arctiin, high adsorption and desorption speed, high adsorption capacity, abundant material sources, low production cost, obvious separation effect and high extraction purity, can be used for extracting arctiin conveniently and quickly, can be used to obtain a semi-finished product of which the content of arctiin is higher than 35% and a final product of which the content of arctiin is higher than 90%, and can overcome the defects of low extraction yield and low extraction purity in the conventional method. The macroporous adsorbent resin, which has the advantages of stable physicochemical properties, large surface area, high exchange speed, high mechanical strength, high antipollution capability and high thermal stability, is used for selectively adsorbing arctiin from the solution in a physical adsorption mode, and thus, the invention has the advantages of high adsorption and desorption speed, and high adsorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying arctiin, in particular to a method for enriching and purifying arctiin in burdock with a macroporous adsorption resin. Background technique: [0002] Burdock, also known as burdock, burdock, evil real, burdock seed, bat thorn, and verbenia, is an ancient medicinal and edible vegetable in my country. Burdock is a biennial herb with a height of 1-2m. Basal leaves clustered, large, with long stalks; cauline leaves broadly ovate or cordate, margins wavy or serrate, base cordate, densely white pubescent below. The inflorescences are numerous, arranged in a corymb shape; the involucre is spherical, the involucre is lanceolate, and the apex has a short hook; the flowers are light red, all tubular. Achenes oval, ribbed, taupe, with short bristly pappus. Burdock fruit contains arctiin, which is hydrolyzed to form arctigenin and glucose. It also contains ma...

Claims

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Application Information

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IPC IPC(8): C07H15/26C07H1/08
Inventor 姚德坤姚德利闫峰黄运生姚航郑君
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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