Cyclic icaritin aglycon as well as preparation method and application of cyclic icaritin aglycon

Abstract

The invention discloses cyclic icaritin aglycon the structural formula of which is shown in the specification. The preparation method of the cyclic icaritin aglycon comprises the following steps: (1) smashing dried epimedium or cutting the dried epimedium into segments, adding water and heating for extraction, filtering the extract to obtain concentrated liquor; (2) carrying out macroporous resin chromatography purification on the concentrated liquor, after the macroporous resin fully absorbs the concentrated liquor, eluting with water until the eluent is colourless, removing the eluent, then eluting with 20-50% methyl alcohol or ethanol, collecting the eluent, recovering the alcohol or ethanol, and then drying; and (3) adding a strong acid methyl alcohol or ethanol solution in the obtained dried substance from the step (2), wherein the volume ratio of dried substance to strong acid methyl alcohol or ethanol solution is (2-6): 100, heating and refluxing after fully stirring, recovering the methyl alcohol or ethanol under reduced pressure, extracting the concentration liquor with ethyl acetate, boiling the solvent off so as to obtain the crude cyclic icaritin aglycon. The prepared cyclic icaritin aglycon (the epimedium content is 90%) can be used for resisting oxidation, resisting bacterium, improving cardiovascular, resisting osteoporosis, resisting inflammatory, enhancing immunity and improving estrogen level.

Description

Cycloicariin aglycon and its preparation method and application technical field The invention relates to cycloicariin aglycone, a preparation method thereof and an application in the preparation of medicines and health care products, and belongs to the technical field of natural medicine extraction. Background technique Epimedium has a long history of medicinal use. There are five kinds of Epimedium currently used in Chinese Pharmacopoeia: Epimedium, Epimedium Cardiac, Epimedium Sagittarius, Epimedium Korean and Epimedium Wushan. The research on the medicinal components of Epimedium is currently mainly focused on the total glycosides of Epimedium and icariin, and there is no report on the derivatives of the main components in Epimedium and their biological activities. Contents of the invention The object of the present invention is to provide a kind of cyclic icariin aglycon isolated and extracted from Epimedium. Another object of the present invention is to provide ...

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Problems solved by technology

The research on the medicinal components of Epimedium is currently mainly focused on the total glycosides of Epimedium and icariin, and there is no report on the derivatives and biological activities of the main components in Epimedium

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