Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Angiotensin I transferase inhibitor and preparation method and application thereof

A conversion enzyme inhibitor, angiotensin technology, applied in the direction of cardiovascular system diseases, peptides, fermentation, etc., to achieve the effect of reducing high blood pressure, no toxic side effects, and low cost

Inactive Publication Date: 2011-06-15
DALIAN FISHERIES UNIVERSITY
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Caputolil, an existing synthetic compound for the treatment of high blood pressure, is an angiotensin I converting enzyme inhibitor, but because it is synthesized from chemicals, it has many side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Angiotensin I transferase inhibitor and preparation method and application thereof
  • Angiotensin I transferase inhibitor and preparation method and application thereof
  • Angiotensin I transferase inhibitor and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0028] 1. Intravenous injection animal experiments

[0029] Select 20 spontaneously hypertensive rats with an average systolic blood pressure of 195mmHg as the experimental model. After the rats were raised for one week, they were divided into 2 groups, each with 10 rats. Intravenous injection at a dose of 5-20 mg / kg body weight, the results showed that the blood pressure of the rats in the control group continued to rise after 1 week, while the blood pressure of the spontaneously hypertensive rats in the treatment group dropped significantly, from the average systolic blood pressure from 195mmHg to 162mmHg , indicating that this peptide has an obvious effect of lowering blood pressure.

[0030] 2. Animal experiment by gavage

[0031] Select 20 spontaneously hypertensive rats with an average systolic blood pressure of 185mmHg as the experimental model. After the rats are fed for a week, they are divided into groups, and the extract of the embodiment of the present invention i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an angiotensin I transferase inhibitor and a preparation method and application thereof. The preparation method comprises the following steps of: performing enzymolysis on oyster serosity serving as a raw material to generate oyster protein enzymolysis solution; and further separating and purifying the oyster protein enzymolysis solution to obtain new peptide with an amino acid sequence of Vel Tyr Pro Trp Thr Gln Arg Phe. A test proves that the new peptide is the effective angiotensin I transferase inhibitor, has the advantages of no toxic or side effect, high safety, low cost, capability of industrialized production and the like, and can be widely applied to the preparation of medicaments for reducing blood pressure and health-care products.

Description

Technical field: [0001] The invention relates to an angiotensin I-converting enzyme (ACE) inhibitory peptide, in particular to an angiotensin I-converting enzyme inhibitor that uses oysters as raw materials, has no toxic side effects, high safety, low cost and can be produced industrially , preparation method and application thereof. Background technique: [0002] Hypertension is one of the most common cardiovascular diseases. It can cause damage to the brain, cardiovascular system, and kidneys. It is an important factor causing stroke, heart failure, and coronary heart disease, which seriously threatens human health. Angiotensin I-converting enzyme plays an important role in blood pressure regulation in the human renin-angiotensin system and kallikrein-kinin system. It can convert angiotensin I into angiotensin II, so that Peripheral small arteries and vascular smooth muscle contract, while stimulating the secretion of aldosterone, and promoting the human kidney to Na + 、...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K7/06C12P21/06C07K1/36A61K38/08A61P9/12
Inventor 胡建恩汪秋宽李伟赵前程曲敏马驰宇黄晓娟王刚陈玮
Owner DALIAN FISHERIES UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com