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Cyclic lipopeptides for use as taste modulators

A cyclolipopeptide, lipopeptide technology, used in peptides, applications, food preparation and other directions

Inactive Publication Date: 2011-06-22
NUTRINOVA NUTRITION SPECIALTIES & FOOD ENGREDIENTS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] However, it can be concluded from recent studies that fructose does not show differences in the effects on blood glucose, insulin, leptin and ghrelin compared to sucrose

Method used

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  • Cyclic lipopeptides for use as taste modulators
  • Cyclic lipopeptides for use as taste modulators
  • Cyclic lipopeptides for use as taste modulators

Examples

Experimental program
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Embodiment 1

[0068] Detection of Bacillus subtilis Surfactin Sweet Taste Enhancer Activity in Recombinant Human Taste Receptor-Dependent T1R2 / T1R3-Dependent Cell-Based Assay

[0069] In wild-type taste cells - eg, in human taste buds - signaling is presumed to be via the G-protein gustducin and / or via Galpha-i type G-proteins. Encountering sweet-tasting ligands, heterodimeric human taste receptor T1R2 / T1R3 responses, with concomitant induction of second messenger molecules; elicit cAMP levels in response to most sugars or elicit calcium levels in response to most artificial sweeteners (Margolskee J . Biol Chem. (2002) 277, 1-4).

[0070] To analyze the function and activity of Surfactin, the heterodimeric T1R2 / T1R3 sweet taste sensor has been utilized in a calcium-dependent cell-based assay. T1R-type taste receptors have been infected with the polycistronic plasmid vector pTrix-Eb-R2R3 in the HEK293 cell line stably expressing the promiscuous mouse G-α-15G-protein.

[0071] For the gener...

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Abstract

The invention relates to the use of one or more cyclic lipopeptides, such as surfactins A, B1 and C and derivatives and mixtures thereof, as a taste modulator and / or sweetness enhancer for comestible compositions containing at least one natural or artificial sweetener. The comestible compositions include food, beverages, medicinal products and cosmetics and contain preferably mono-, di- or oligosaccharides as sweeteners. The invention further relates to said comestible compositions containing a cyclic lipopeptide as taste modulator.

Description

field of invention [0001] The present invention relates to the use of molecules belonging to the group of cyclic lipopeptides as taste modulators, preferably in edible compositions containing at least one sweetener. In a preferred embodiment, surfactin is used for the purposes of the present invention. Furthermore, the present invention relates to methods for modulating the taste and / or aftertaste of said edible compositions as well as these compositions containing at least one cyclic lipopeptide as taste modulator. Background of the invention [0002] Surfactin is a microbially derived cyclic lipopeptide that acts as a biosurfactant due to its amphoteric properties. For chemical classification, they can be named cycloaliphatic depsipeptides, which is a special form of depsipeptides. Often by fungi (e.g., Metarhizium sp. or Cladobotryum sp.) and bacteria (e.g., Pseudomonas syringae (US 5,830,855) or Bacillus subtilis (EP 0761682 B1)) in ring form (cyclic depsipeptides) to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/236A23L1/22A23L27/00A23L27/21A23L27/30
CPCA23L1/2361A23L1/22091A23L27/88A23L27/31A23L27/30C07K7/56A23L2/60
Inventor M·克罗恩H·津克
Owner NUTRINOVA NUTRITION SPECIALTIES & FOOD ENGREDIENTS GMBH
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