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Applications and preparation method of saussurea total sesquiterpene lactone

A technology of sesquiterpene lactone and snow lotus, applied in the field of medicine, can solve problems such as formula, irrelevance of efficacy and the like

Active Publication Date: 2013-08-28
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are two kinds of "Xuelian" and "Capsule" in the name, which are Fufang Xuelian Capsule and Fufang Xuelian Capsule, but their composition and efficacy are not related to the research content of this topic.

Method used

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  • Applications and preparation method of saussurea total sesquiterpene lactone
  • Applications and preparation method of saussurea total sesquiterpene lactone
  • Applications and preparation method of saussurea total sesquiterpene lactone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Solvent extraction of total sesquiterpene lactones:

[0076] ① Take dried snow lotus, crush it, add 10 times the amount of ethanol solution with a volume concentration of 95%, soak and extract at 20-30°C, repeat several times until the color of the extract becomes lighter, filter the extract, and concentrate under reduced pressure to The specific gravity is about 1.40g / ml, and the alcohol extraction extract is obtained;

[0077] ② Disperse the extract with 3 times the amount of water to obtain a water dispersion system, and then extract it several times with petroleum ether equivalent to 1 / 3 times the volume of the water dispersion system, until the color of the extract becomes lighter, combine the petroleum ether extract, and depressurize Concentrated, freeze-dried.

Embodiment 2

[0079] Solvent extraction of total sesquiterpene lactones:

[0080] ①Take the dried snow lotus, crush it, add 15 times the amount of ethanol solution with a volume concentration of 50%, soak and extract at 30-40°C, repeat several times until the color of the extract becomes lighter, filter the extract, and concentrate under reduced pressure to The specific gravity is about 1.40g / ml, and the alcohol extraction extract is obtained;

[0081] ② Disperse the extract with 2 times the amount of water to obtain a water dispersion system, and then extract it several times with petroleum ether equivalent to 1 times the volume of the water dispersion system, until the color of the extract becomes lighter, combine the petroleum ether extracts, concentrate under reduced pressure, Freeze dried.

Embodiment 3

[0083] Carbon dioxide supercritical extraction to extract total sesquiterpene lactones:

[0084] Take dried snow lotus medicinal materials, crush them, and add Chaolin CO after sieving 2 In the extraction pool, the parameter setting range is: extraction pressure 10-15 MPa; extraction pool temperature 35-40 °C, analytical pressure 3.0 MPa, temperature 50 °C, dynamic extraction for 120 min, CO 2 The flow rate is 30 L / h.

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Abstract

The invention discloses applications and a preparation method of saussurea total sesquiterpene lactone, belonging to the technical field of medicines and relating to the applications of the saussurea total sesquiterpene lactone in preparing antihypoxic drugs. The total sesquiterpene lactone can be extracted through a solvent method, a carbon dioxide supercritical extraction method and a petroleumether reflux method. Experiments find and prove that medicaments obtained in antihypoxic medicament preparation have significant antihypoxic effect. The preparation method provided by the invention is simple, and can be effectively used for extracting the total sesquiterpene lactone in saussurea.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application and preparation method of total sesquiterpene lactones of snow lotus. Background technique [0002] Saussurea involucrata is the whole flowering plant of Saussurea Laniceps Hand.-Mazz., Saussurea involucrata Kar.et.Kin, and Saussurea medusa Maxim. The use of snow lotus as a medicine was first recorded in the ancient Tibetan medicinal literature "Yuewang Yaozhen" in the 8th century, and then it was recorded in the classic "Northwest Territories", "Western Medical Code" and "Compendium of Materia Medica Supplements" in the Qing Dynasty. Previous literature reports on the chemical research results of snow lotus show that its main components include flavonoids, alkaloids, coumarins, lignins and sesquiterpenes and other chemical components. Snow lotus is warm in nature and slightly bitter in taste. It has the functions of dispelling cold and dehumidification, strengthe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K36/285A61P39/00
Inventor 马慧萍贾正平樊鹏程景临林
Owner 中国人民解放军联勤保障部队第九四〇医院
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