Fluorescent compounds for the diagnosis of infections, production method, and applications thereof

Abstract

The invention relates to novel fluorescent compounds analogous to alkyl phospholipids, containing highly photostable fluorescent groups in the structure thereof and emitting in the visible spectrum wavelength range. Said compounds are easily introduced into micro-organisms, enabling the detection and identification of said organisms by means of fluorescence microscopy. The novel fluorescent compounds can also diagnose, rapidly and easily, the presence of pathogenic micro-organisms characterized by their resistance to treatment with alkyl phospholipids.

Description

technical field [0001] The present invention relates to pharmaceutical compositions for the clinical diagnosis of infectious diseases, preferably ophthalmic diseases, and for the identification of microorganisms. Background technique [0002] The prevention and correct treatment of certain diseases of the eye require the identification of the various microorganisms that can cause infection of this organ. Many of these eye infections can have a serious impact on a patient's vision if not diagnosed and treated early. It is therefore necessary in some cases to test for pathogens directly infecting the organ, by taking a small sample of tissue fragments representative of the susceptible tissue from the eye (biopsy) or by examining physiological fluids in contact with said tissue (in this case the tears) for analysis. Common methods for the detection of microorganisms in samples are often based on obtaining cultures that increase the number of possible pathogens to aid subseque...

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Problems solved by technology

Recently, accidents due to contamination of contact lens care solution with Fusarium fungus have had serious consequences for a large number of patients and resulted in huge financial losses for manufacturers (Chang, D.C; Grant, G.B.; O'Donnell, K.; Wannemuehler, K.A.; Noble-Wang, J.; Rao, C.Y.; Jacobson, L.M.; Crowell, C.S.; , A.; Fridkin, S.K.; Park, B.J., Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution. JAMA 2006, 296, (8), 953-63; Centers for Disease Control and Prevention (CDC), Update: Fusarium keratitis -United States, 2005-2006. MMWR Morb Mortal Wkly Rep 2006, 55, (20), 563-4)

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