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Compound preparation for treating cervical spondylotic myelopathy and preparation method thereof

A technology for cervical spondylotic myelopathy and compound preparations, which is applied in the field of compound preparations and preparations for the treatment of cervical spondylotic myelopathy, to achieve the effects of ensuring curative effect, protecting the environment, and removing impurities

Active Publication Date: 2013-03-13
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Su Wen·Ni Tiao Lun" said: "If the kidneys do not grow, the marrow will not be full.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get the bulk drug of the following proportioning range in parts by weight:

[0030] Astragalus 60~30, Danshen 30~15, Cistanche 30~15, artificial musk 2~0.5,

[0031] Add 10 times the amount of Danshen 90% ethanol and extract by heating under reflux for 1.5 hours, and recover the solvent; add 8 times the amount of 90% ethanol to heat and reflux for extraction for 1.5 hours, and recover the solvent; after weighing Astragalus and Cistanche, add 10 times the amount of water, Soak for 40min, decoct 2 times, 1h each time, and combine the decoction. Combine the above three solutions, add 65% ethanol to make the alcohol content reach 60%, recover the ethanol, concentrate, add dextrin, spray dry to make fine powder, add artificial musk, and dry granulate to make granules.

Embodiment 2

[0033] Get the bulk drug of the following proportioning range in parts by weight:

[0034] Astragalus 55~25, Salvia miltiorrhiza 25~10, Cistanche 25~10, artificial musk 1.5~0.5,

[0035] Salvia miltiorrhiza was extracted by heating reflux twice with 90% ethanol, and the extract was stored in another container; after weighing Astragalus and Cistanche, add 10 times the amount of water, soak for 40 minutes, decoct twice, each time for 1 hour, and combine the decoction; the above three Combine the two solutions, add 75% ethanol to make the alcohol content reach 60%, recover the ethanol, concentrate, add dextrin, spray dry to make fine powder, add artificial musk, and dry granulate to make granules, or add conventional auxiliary materials to prepare Formed into tablets, capsules, dripping pills.

Embodiment 3

[0037] Get the raw material medicine of following weight ratio scope:

[0038] Astragalus 50~20, Danshen 30~15, Cistanche 30~15, artificial musk 1.5~0.5,

[0039] Add 10 times the amount of Danshen 90% ethanol and heat and reflux for 1.5 hours to recover the solvent; add 8 times the amount of 90% ethanol to heat and reflux for 1.5 hours to recover the solvent; add 10 times the amount of water for Astragalus and Cistanche, soak for 40 minutes, Decoct twice, each time for 1 hour, and combine the water decoction; combine the above three solutions, add 65% ethanol to make the alcohol content reach 60%, recover the ethanol, concentrate, add dextrin, and spray dry to make a fine powder. Add artificial musk, dry granulate to make granules or make capsules according to conventional methods.

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PUM

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Abstract

The invention relates to a compound preparation for treating cervical spondylotic myelopathy and a preparation method thereof, belonging to the field of traditional Chinese medicines. The compound preparation is prepared from effective components and medical auxiliary materials, wherein the effective components comprise milk vetch, red sage root, broomrape and artificial musk. In the invention, water or ethanol extracts of the raw medicines and the medical auxiliary materials are prepared into granules, tablets, capsules or dripping pills. The animal experiment proves that the compound preparation can obviously relieve the functional damage after chronic spinal compression, and can be used for treating cervical spondylotic myelopathy by relieving edema, reducing apoptosis of nerve cells, promoting vascular repair, improving blood circulation, improving microenvironment of neurons, promoting expression of neurotrophic factors of neurons, restoring intercellular contact and the like. The compound preparation can overcome the defects that the Chinese medical decoction needs to be temporarily decocted before being taken, is easy to mildew and deteriorate after being stored for a long time and brings inconvenience for patients; and the compound preparation can enhance the treatment effect and reduce the recurrence, thereby conveniently meeting the requirements of patients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound preparation for treating cervical spondylotic myelopathy and a preparation method thereof. Background technique [0002] Cervical spondylotic myelopathy is a spinal cord compression or / and spinal cord blood supply disorder due to cervical degenerative changes, and thus produces a corresponding spinal cord dysfunction disease. The early symptoms of the disease are bilateral or unilateral lower extremity tightness and numbness, pain and stiffness, soreness, heaviness and weakness, weak legs, easy to fall, clumsy gait, feeling of stepping on cotton, and then one or both upper limbs numbness, pain and burning sensation , weakened hand muscles, trembling, inflexibility, unstable holding, muscle atrophy, and severe cases of quadriplegia. The examination found that the hypoesthesia first appeared in the lower limbs, gradually upward, the sensory plane...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/64A61P19/08A61K31/122
Inventor 王拥军施杞周泉崔学军张宁徐乐勤周重建卞琴梁倩倩李晨光唐德志舒冰赵永见刘书芬卢盛周永全王晶
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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