Compound preparation for treating primary osteoporosis and preparation method

A technology for osteoporosis and compound preparations, which can be used in medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc., and can solve the problems of patients with mildew and deterioration and inconvenience

Active Publication Date: 2013-07-24
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been a large number of clinical reports that the treatment of osteoporosis with Zuogui pills has achieved good curative effect, but there are still the following deficiencies in medical practice: the curative effect needs to be consolidated, and recurrence should be reduced as much as possible, and the traditional Chinese medicine decoction needs to be temporarily decocted before taking , long-term home is easy to mildew and deterioration and inconvenience to patients, etc.

Method used

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  • Compound preparation for treating primary osteoporosis and preparation method
  • Compound preparation for treating primary osteoporosis and preparation method
  • Compound preparation for treating primary osteoporosis and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The following raw materials are obtained in proportions by weight: 30-20 parts by weight of medlar, 30-20 parts of cornus, 30-20 parts of Chinese yam, 30-20 parts of dodder, 30-20 parts of antler gum, 30-20 parts of tortoise shell gum, 45-30 parts of Dashudi , Ligustrum lucidum 45-30, Shouwu 45-30, soak for 1 hour, decoct 1-3 times, decoct 0.5-1.5 hours each time, add 10-14 times of water for the first decoction, add 6-3 times of water for the second and third decoctions 10 times, combine the decoction, filter, and concentrate the filtrate to an extract with a relative density of 1.05-1.30 at a temperature of 60-70°C;

[0039] ② Add ethanol to the above-mentioned ① extract until the concentration of ethanol is 50% to 80%, let it stand overnight, and alcohol precipitates. Filtrate, recover ethanol from the filtrate at a temperature of 60-70°C, and concentrate to a thick extract with a relative density of 1.35-1.40;

[0040] ③ the above-mentioned ② concentrated extract i...

Embodiment 2

[0043]Take the following proportioning raw materials by weight: wolfberry fruit 25-15, cornus 25-15, yam 25-15, dodder 25-15, antler gum 25-15, tortoise shell gum 25-15, dashudi 38-22 , Ligustrum lucidum 38-22, Shouwu 38-22. Soak for 1 hour, decoct for 2 times, each time for 1 hour, add 14 times the amount of water for the first decoction, add 10 times the amount of water for the second decoction, combine the decoction liquid, filter, and concentrate the filtrate to an extract with a relative density of 1.05-1.07 ;

[0044] ②Add ethanol to the above-mentioned ①extract solution until the ethanol concentration is 60%; Filtrate, recover ethanol from the filtrate at a temperature of 60-70°C, and concentrate to a thick extract with a relative density of 1.35-1.40;

[0045] ③ the above-mentioned ② concentrated extract is dried under reduced pressure at 70-80° C., pulverized into fine powder, and passed through a 60-mesh sieve to obtain the extract powder of the drug component;

...

Embodiment 3

[0048] Take the following proportioning raw materials by weight: wolfberry fruit 20-10, cornus 20-10, yam 20-10, dodder 20-10, antler gum 20-10, tortoise shell gum 20-10, dashudi 30-15 , Ligustrum lucidum 30-15, Shouwu 30-15, soak for 1 hour, decoct 2 times, decoct for 1 hour each time, add 14 times of water for the first decoction, add 10 times of water for the second decoction, combine the decoction liquid, filter, The filtrate is concentrated to an extract with a relative density of 1.05 to 1.07;

[0049] ②Add ethanol to the above-mentioned ①extract solution until the ethanol concentration is 60%; Filtrate, recover ethanol from the filtrate at a temperature of 60-70°C, and concentrate to a thick extract with a relative density of 1.35-1.40;

[0050] ③ the above-mentioned ② concentrated extract is dried under reduced pressure at 70-80° C., pulverized into fine powder, and passed through a 60-mesh sieve to obtain the extract powder of the drug component;

[0051] ④ Accordin...

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Abstract

The invention belongs to the traditional Chinese medicine field, and relates to a traditional Chinese medicine preparation for treating primary osteoporosis and a preparation method. The compound preparation follows a therapeutic principle of nourishing kidney yin, and employs water extracts of wolfberry, cornus officinalis, Chinese yam, semen cuscutae, deerhorn glue, glue of tortoise plastron, big rehmanniae vaporata, ligustrum lucidum and by mixing with an auxiliary material, the above materials are pelletized and performed with tabletting to prepare the compound preparation. The result of the animal experiments shows that the compound preparation bone resorption and bone formation with high level due to ovariectomy can be reduced, a balance state that the bone formation is greater than the bone resorption can be recovered, and the bone mass is increased; osteocalcin secretion can be promoted, so that the lipoblast differentiation capability can be inhibited. The compound preparation can improve the symptom of primary osteoporosis, reduce recurrence and consolidate curative effect; and can avoid the inconvenience of temporary decoction and easy deterioration for long-term placing before administration of a traditional Chinese medicine decoction for the patients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound preparation for treating primary osteoporosis and a preparation method thereof. Background technique [0002] The prior art discloses that osteoporosis (Osteoporosis, OP) is a systemic skeletal disease characterized by decreased bone mass and increased bone fragility, resulting in fractures. At present, there is no ideal drug for clinical treatment. Although hormone replacement drugs can achieve certain therapeutic effects, they also produce many side effects. In recent years, studies have found that traditional Chinese medicine has certain advantages in the treatment of osteoporosis. [0003] Traditional Chinese medicine classifies osteoporosis into the category of "bone impotence" and "bone impediment", and believes that kidney deficiency is the root cause of osteoporosis, and the treatment method of nourishing the kidney will achieve better...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P19/10A61K35/32A61K35/56A61K35/586
Inventor 王拥军杨铸卞琴徐浩杨洲唐德志杨锋赵永见刘书芬施杞
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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