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Traditional Chinese medicine composition as well as preparation, preparation method and application thereof

A composition and technology of traditional Chinese medicine are applied in the field of preparation and preparation of traditional Chinese medicine compositions for treating hyperuricemia and their preparations, which can solve the problems of low solubility, high price, limited effect, etc. The effect of swelling suppression

Active Publication Date: 2021-04-30
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the reabsorption process of uric acid is inhibited, a large amount of uric acid will enter the kidney, and weakly acidic uric acid will have lower solubility in urine with a lower pH, and it is easier to precipitate crystals in the kidney, causing kidney damage
Uracase representative drug is expensive and limited

Method used

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  • Traditional Chinese medicine composition as well as preparation, preparation method and application thereof
  • Traditional Chinese medicine composition as well as preparation, preparation method and application thereof
  • Traditional Chinese medicine composition as well as preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh the following raw materials: 15g coix root, 10g fennel, 5g blancia, 6g clematis, 5g loofah. After weighing the raw material, add water, soak, add water to extract 3 times, each time for 1h, combine the decoction, filter, and concentrate the filtrate under reduced pressure to extract with a pair density of 1.10-1.15 (60°C), dry under reduced pressure, Crush, sieve, add appropriate amount of dextrin, use ethanol solution as wetting agent, make soft material, granulate, dry, and granulate to obtain.

Embodiment 2

[0033] The following raw materials were weighed: 20g coix root, 12g fennel, 6g blancia, 9g clematis, and 9g loofah. After weighing the raw material, add water, soak, add water to extract 3 times, each time for 1h, combine the decoction, filter, and concentrate the filtrate under reduced pressure to extract with a pair density of 1.10-1.15 (60°C), dry under reduced pressure, Crush, sieve, add appropriate amount of dextrin, use ethanol solution as wetting agent, make soft material, granulate, dry, and granulate to obtain.

Embodiment 3

[0035] Weigh the following raw materials: 30g coix root, 15g fennel, 10g blancia, 10g clematis, 12g loofah. After weighing the raw material, add water, soak, add water to extract 3 times, each time for 1h, combine the decoction, filter, and concentrate the filtrate under reduced pressure to extract with a pair density of 1.10-1.15 (60°C), dry under reduced pressure, Crush, sieve, add appropriate amount of dextrin, use ethanol solution as wetting agent, make soft material, granulate, dry, and granulate to obtain.

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hyperuricemia, which is prepared from 15-30g of coix root, 10-15g of yam rhizome, 5-10g of cowherb seed, 6-10g of clematis root and 5-12g of loofah sponge. The invention further provides a traditional Chinese medicine compound preparation for treating hyperuricemia and a preparation method and application thereof. According to the traditional Chinese medicine composition and the preparation thereof, hyperuricemia is treated by reducing uric acid, and a series of diseases such as gouty arthritis and uric acid nephropathy caused by hyperuricemia are treated.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating hyperuricemia and its preparation, preparation method and application. Background technique [0002] Hyperuricemia (HUA) refers to the state of adult plasma uric acid concentration ≥ 7mg / dL (male) or 5.6mg / dL (female), mainly due to excessive production of uric acid and / or Metabolic diseases caused by decreased uric acid excretion. [0003] Gout is an inflammatory response caused by the deposition of monosodium urate crystals in the joint cavity, cartilage, and kidneys, and is directly related to hyperuricemia caused by purine metabolism disorders and / or reduced excretion of uric acid. High uric acid levels act on vascular tissue, pancreatic islets, and insulin targets to cause high expression of ROS, activation of RAS, and release of inflammatory factors, which in turn lead to vascular rem...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P19/06A61P13/12A61P19/02
CPCA61K36/36A61K36/42A61K36/716A61K36/8945A61K36/8994A61K2236/331A61P13/12A61P19/02A61P19/06A61K2300/00
Inventor 张磊魏莉张瑾王健英
Owner SHANGHAI UNIV OF T C M
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