Ginsenoside Rg1 molecular imprinting material and preparation method and application thereof

Abstract

The invention discloses a preparation method of a ginsenoside Rg1 molecular imprinting material, and a method for separating and purifying an Rg1 mimetic in a natural product by using the material as a solid-phase extracting agent. The material belongs to novel separating materials, can serve as a fixing phase of a solid-phase extraction column, is used for quickly, effectively and directionally separating and gathering the Rg1 mimetic from the Chinese medicine to obtain a target component with high extraction rate, and has extremely high application value.

Description

Technical field: [0001] The patent of the present invention relates to the field of synthesis and its application in targeted separation, and specifically relates to the preparation of ginsenoside Rg1 molecularly imprinted material and the method of using the material as a solid phase extraction agent to separate and purify Rg1 mimics in plants. Background technique: [0002] (1) Ginsenoside Rg1 has the effect of promoting the proliferation of neural stem cells, and plays an important role in the treatment of stroke sequelae, neurodegenerative diseases and other diseases. In view of the lack of clinical drugs that promote the proliferation of neural stem cells, it is of great significance to use Rg1 as a template to synthesize molecularly imprinted materials for targeted screening of active ingredients from traditional Chinese medicines, ethnic medicines, and natural plants. [0003] (2) The ingredients contained in Chinese herbal medicine are complex. In order to improve th...

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Problems solved by technology

[0003] (2) The ingredients contained in Chinese herbal medicine are complex. In order to improve the therapeutic effect of Chinese herbal medicine, it is necessary to extract the active ingredients as much as possible and remove the ineffective and toxic ingredients.

The separation and extraction of active ingredients of traditional Chinese medicine often use silica gel column, C 18 Bonded phase column, Al 2 o 3 Columns, etc. use the difference in the adsorption coefficient of the components to achieve separation, but the biggest disadvantage is poor selectivity and low enrichment capacity, especially for some active compounds with complex structures, multi-chiral carbon atoms, and low content, it is difficult to separate and purify. Using these conventional Separation methods often require repeated operations, the extraction rate is extremely low, and the chiral configuration may be changed and inactivated

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