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Medicinal composition for treating diabetes

A composition and technology for diabetes, applied in the field of medicine, can solve the problems of not finding the relevant literature and patent reports of compound bromocriptine and metformin hydrochloride pharmaceutical composition, and achieve the effects of low price, reduced side effects and good curative effect

Inactive Publication Date: 2011-09-21
吴四清 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Through the search, no relevant literature and patent reports on the pharmaceutical composition of compound bromocriptine and metformin hydrochloride were found

Method used

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  • Medicinal composition for treating diabetes
  • Medicinal composition for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A pharmaceutical composition for treating diabetes comprises the following components in mass percentage:

[0027] Bromocriptine 0.7%,

[0028] Metformin Hydrochloride 90%,

[0029] Lactose monohydrate 8%,

[0030] Magnesium Stearate 1.3%,

[0031] The production method is as follows:

[0032] Pass the bromocriptine and metformin hydrochloride through 80-mesh sieve respectively, mix evenly, and use the equal-volume incremental method to fully stir to make them even, then add magnesium stearate, mix evenly, and then pack into No. 1 capsules. The unit capsule contains 3.5mg of bromocriptine and 450mg of metformin hydrochloride.

[0033] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 2

[0035] A pharmaceutical composition for treating diabetes comprises the following components in mass percentage:

[0036] Bromocriptine 0.7%,

[0037] Metformin Hydrochloride 80%,

[0038] Microcrystalline Cellulose 12%,

[0039] Hydroxypropyl Methyl Cellulose 5.8%,

[0040] Micronized silica gel 0.8%,

[0041] Magnesium Stearate 0.7%.

[0042] The production method is as follows:

[0043] Bromocriptine, microcrystalline cellulose, and hydroxypropyl methylcellulose were passed through 80 mesh sieves respectively, mixed evenly, and mixed with metformin hydrochloride by an equal-volume incremental method, fully stirred to make them uniform, and set aside; 50% ethanol solution was added to In the mixed powder, make soft materials, granulate with a 24-mesh sieve, dry, granulate with a 20-mesh sieve, add micropowder silica gel and magnesium stearate, mix well, and press a suitable die to form a tablet. The unit tablet contains 3.5 mg of bromocriptine and 400 mg of metformin h...

Embodiment 3

[0046] A pharmaceutical composition for treating diabetes comprises the following components in mass percentage:

[0047] Bromocriptine 0.7%,

[0048] Metformin Hydrochloride 75%,

[0049] Ethylcellulose 15.8%,

[0050] Polyacrylic resin 8.5%,

[0051] The slow-release tablet of the required specifications can be made according to the conventional slow-release tablet process. A unit sustained-release tablet contains 3.5 mg of bromocriptine and 375 mg of metformin hydrochloride.

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Abstract

The invention discloses a medicinal composition for treating diabetes, which comprises bromocriptine and metformin hydrochloride. In the medicinal composition for treating diabetes, the dose of a main medicine is small; and compared with other compound preparations of metformin hydrochloride, the side effect is reduced greatly, patients can taken the medicinal composition for a long time, and the obedience in the patients is high. In addition, the medicinal composition also has the advantage that the medicine price is lower than other metformin hydrochloride compound preparation treatment medicines.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating diabetes. Background technique [0002] The latest epidemiological survey in my country shows that the prevalence of diabetes among adults over 20 years old is 9.7% (10.6% for men and 8.8% for women), and the total number of diabetic patients has reached 92,400, which is the largest number of diabetic patients in the world. highest country. In addition, the prevalence of pre-diabetes is 15.5% (16.2% for men, 14.9% for women), and the total number has reached 104.82 million. Therefore, there are a large number of newly diagnosed type 2 diabetes patients in my country every year. Effective management of the population is an important part of reducing disability and death due to complications of diabetes. [0003] At present, the main treatment for patients with type 2 diabetes is still to control blood sugar to reach the target...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/48A61K31/155A61P3/10
Inventor 吴四清唐俊葛海涛
Owner 吴四清
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