Compound preparation of Fasudil and Beraprost as well as preparation method and application thereof

A technology of beraprost and fasudil, applied in the field of pharmacy, can solve problems such as unsatisfactory effects and complicated treatment
CN102188433AInactive Publication Date: 2011-09-21TIANJIN CHASE SUN PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN CHASE SUN PHARM CO LTD
Publication Date
2011-09-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the pharmaceutical field and relates to a compound preparation of Fasudil and Beraprost as well as a preparation method and application thereof to treating pulmonary hypertension. The compound preparation in the invention comprises Fasudil, Beraprost and auxiliary materials chosen from auxiliary materials acceptable in pharmacy, such as a disintegrating agent, an adhesive, an excipient, diluents, a lubricant, framework materials used for controlling the release of active ingredients in slow and controlled release agents, and the like. Proper carriers are chosen according to different types of drugs.
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Description

technical field

[0001] The invention belongs to the field of pharmacy and relates to a compound preparation of fasudil and beraprost and its preparation method and application, which are used for the treatment of pulmonary hypertension. Background technique

[0002] Fasudil [hexahydro-1-(5-isoquinolinesulfonyl)-homopiperazine, Fasudil] is a Rho kinase inhibitor. Its molecular weight is 327.83 and its molecular formula is C 14 h 17 N 30 2S·HCl, structural formula:

[0003]

[0004] Studies have confirmed that the Rho kinase pathway is one of the important pathogenic pathways leading to pulmonary artery constriction and pulmonary vascular remodeling in patients with pulmonary arterial hypertension. For pulmonary hypertension, fasudil can reduce the activity of Rho kinase, inhibit the contraction of pulmonary artery vascular smooth muscle, dilate pulmonary arteries, reduce pulmonary artery resistance, and reduce pulmonary arterial pressure.

[0005] Beraprost is a deriv...

Claims

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