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Laser micropore porcine acellular dermal matrix and preparation method thereof

A technology of decellularized dermis and dermal matrix, which is applied in the field of laser microporous porcine acellular dermal matrix and its preparation, can solve the problems of unsatisfactory repair effect, uneven distribution, and excessive mesh, so as to reduce the formation of scars, The micropore distribution is uniform and fine, and the effect of improving the survival rate

Inactive Publication Date: 2011-09-21
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the mesh of the dermal matrix is ​​too large, and the distribution is not uniform enough, resulting in shrinkage of the wound surface and unsatisfactory repair effect

Method used

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  • Laser micropore porcine acellular dermal matrix and preparation method thereof
  • Laser micropore porcine acellular dermal matrix and preparation method thereof
  • Laser micropore porcine acellular dermal matrix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of laser microporous porcine acellular dermal matrix, comprising the following steps:

[0026] A. Set the parameters of the laser processing equipment so that the output energy is at least 10,000 watts per square millimeter, and it can break down quickly in a very short time in a micro-spot area; the laser puncture step is 1 mm, and the aperture is 0.1 mm;

[0027] B. Take a piece of porcine acellular dermal matrix sample from sterile water for injection, which is a 5 cm * 5 cm square, and quickly fix it on the processing platform of the laser processing equipment by four-point suspension fixation method; four-point suspension fixation The method is to fix the four ends of the porcine acellular dermal matrix sample and ensure that it is suspended to ensure that it can be heated evenly;

[0028] C, making the surface of the porcine acellular dermal matrix sample smooth and the upper and lower surfaces moist; the sample surface has no bumps and folds;...

Embodiment 2

[0033] A preparation method of laser microporous porcine acellular dermal matrix, comprising the following steps:

[0034] A. Set the parameters of the laser processing equipment so that the output energy is at least 10,000 watts per square millimeter, and it can break down quickly in a very short time in a micro-spot area; the laser puncture step is 1 mm, and the aperture is 0.2 mm;

[0035] B. Take a piece of porcine acellular dermal matrix sample from sterile water for injection, which is a square of 5 cm * 4 cm, and quickly fix it on the processing platform of the laser processing equipment by four-point suspension fixation method; four-point suspension fixation The method is to fix the four ends of the porcine acellular dermal matrix sample and ensure that it is suspended to ensure that it can be heated evenly;

[0036] C, making the surface of the porcine acellular dermal matrix sample smooth and the upper and lower surfaces moist; the sample surface has no bumps and fol...

Embodiment 3

[0041] A preparation method of laser microporous porcine acellular dermal matrix, comprising the following steps:

[0042] A. Set the parameters of the laser processing equipment so that the output energy is at least 10,000 watts per square millimeter, and it can break down quickly in a very short time in a micro-spot area; the laser puncture step is 1 mm, and the aperture is 0.13 mm; The laser puncture efficiency is the best when the aperture is 0.13mm;

[0043] B. Take a piece of porcine acellular dermal matrix sample from sterile water for injection, which is a 5 cm * 5 cm square, and quickly fix it on the processing platform of the laser processing equipment by four-point suspension fixation method; four-point suspension fixation The method is to fix the four ends of the porcine acellular dermal matrix sample and ensure that it is suspended to ensure that it can be heated evenly;

[0044] C, making the surface of the porcine acellular dermal matrix sample smooth and the u...

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Abstract

The invention relates to a laser micropore porcine acellular dermal matrix and a preparation method thereof. Pore diameters of micropores in the dermal matrix are between 0.1 and 0.2 millimeter, and space between the micropores is 1 millimeter. The preparation method comprises the following steps of: fixing a porcine acellular dermal matrix sample on a processing platform of laser processing equipment by a four-point suspension fixing method, and regulating parameters of the laser processing equipment, so that the minimum emitting energy of the laser processing equipment is 10,000 watts / millimeter square, wherein the puncture step size of lasers is 1 millimeter, and the pore diameters are between 0.1 and 0.2 millimeter; and performing puncture on the sample to obtain the micropore porcine acellular dermal matrix. By the preparation method, the efficiency of laser puncture is the highest; and in the prepared micropore porcine acellular dermal matrix, the pore diameters are between 0.1 and 0.2 millimeter, the space between the micropores is 1 millimeter, and the micropores are uniform and fine in distribution, so seepage on wound substrates can permeate through uniform meshes to better nourish skin pieces, promote revascularization, improve the survival rate of the skin pieces and reduce the formation of scars during transplantation.

Description

technical field [0001] The invention relates to medical skin tissue engineering technology, in particular to a laser microporous porcine decellularized dermal matrix and a preparation method thereof. Background technique [0002] With the improvement of people's living standards in our country, the requirements for the treatment of acute and chronic skin wounds are also getting higher and higher. Ulcers caused by bedsores, varicose veins, vasculitis, diabetes, etc., and skin defects caused by acute trauma such as burns often make it difficult to repair wounds due to the lack of transplantable autologous skin grafts. Patients also face metabolic disorders caused by skin defects, Threats of pain, infection, sepsis and even death. One of the important reasons for this is that the human dermis cannot regenerate, and the loss of the dermis directly leads to the obvious hyperplasia of scars, which seriously affects the quality of life of patients. Therefore, the development of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/60A61L27/56
Inventor 林才罗旭王平李向阳张鹏
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL COLLEGE
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