Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of silverweed cinquefoil root extract to preparation of anti-AIDS medicament

An anti-AIDS and extract technology, applied in antiviral agents, pharmaceutical formulations, plant raw materials, etc., can solve problems that have not yet been reported in research

Inactive Publication Date: 2011-10-05
LOGISTICS UNIV OF CAPF +1
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bracken has both antiviral and immune-enhancing effects, which makes the extract of Bracken have the possibility of being used in anti-HIV treatment, but so far there has been no research report in this regard

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of silverweed cinquefoil root extract to preparation of anti-AIDS medicament
  • Application of silverweed cinquefoil root extract to preparation of anti-AIDS medicament
  • Application of silverweed cinquefoil root extract to preparation of anti-AIDS medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation process of fern extract:

[0037] Take the dried root tubers of Bracken, pulverize, extract with 70% ethanol aqueous solution under reflux, concentrate under reduced pressure, disperse with hot water, extract and degrease with petroleum ether; filter the water layer to obtain a clear liquid, apply D-101 macroporous resin, first Wash with 3 times the amount of water, and then elute with 30% ethanol aqueous solution with 3 times the volume concentration, collect the fractions, concentrate under reduced pressure, and freeze-dry to obtain a brown powder as the Bracken extract.

[0038] The following is the experimental description of the anti-HIV-1 effect of the fern extract:

[0039] Experiment 1 is a virus inhibition experiment based on TZM-bl.

[0040] 1 method

[0041] The virus was titrated according to the reference literature, and 200TCID50 virus was used for drug activity detection.

[0042] On the first day, TZM-bl cells were inoculated into a 96...

Embodiment 2

[0059] Tablets prepared with fern extract

[0060]

[0061] The above formula is made into tablets according to traditional processing methods.

Embodiment 3

[0063] Capsules prepared with fern extract

[0064] Fern extract 60mg

[0065] Starch 80mg

[0066] Prepared according to the traditional pharmaceutical process, put into No. 2 capsules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of a silverweed cinquefoil root extract to the preparation of an anti-AIDS medicament. The anti-AIDS virus function of the silverweed cinquefoil root extract is observed by performing an in-vitro cytotoxicity test and an HIV (Human Immunodeficiency Virus) in-vitro suppression test. As proved by test results, the silverweed cinquefoil root extract has certain suppression effects on HIV-1 standard strains, clinical strains and pseudo-viruses and has HIV replication suppression activity.

Description

technical field [0001] The invention relates to the application of a medicine, in particular to the application of a fern extract in the preparation of anti-AIDS medicine. Background technique [0002] Since 2003, my country has carried out the "Four Frees and One Care Policy" for AIDS patients, and antiviral drugs have been widely used nationwide. The antiviral treatment regimen has been developed from a single nucleoside reverse transcriptase inhibitor to two nucleoside reverse transcriptase inhibitors and two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitor. Or the combined application of protease inhibitors has greatly reduced the morbidity and mortality of AIDS. However, due to the adverse reactions caused by anti-HIV drugs and the rapid emergence of drug-resistant strains, the application of many anti-HIV drugs is limited. Therefore, discovering and developing highly selective, safe and effective HIV inhibitors is sti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P31/18
Inventor 李灵芝马丽英张永亮王舒刘铁军
Owner LOGISTICS UNIV OF CAPF
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com