Use of cat isaria mycelium

A technology of coryneform spore and mycelium, which is applied to the application field of acute kidney injury medicine, and can solve the problems such as no research report on coryneform spore.

Inactive Publication Date: 2011-11-02
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no research report on t

Method used

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  • Use of cat isaria mycelium
  • Use of cat isaria mycelium
  • Use of cat isaria mycelium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 Animal experiment

[0016] 1. Materials and Methods

[0017] 1.1 Animals, drugs and reagents

[0018] Kunming mice, male, weighing 23-26g, were bred by the Experimental Animal Center of Shanxi Cancer Institute, experimental animal production license number: SCXK (Jin) 2007-0001, experimental animal use license number: SYXK (Jin) 2007- 0002.

[0019] I. felis mycelium (IF) can be cultivated by the method of patent No. ZL02103669.1. Medium: peptone 0.6%, yeast extract 1.2%, sucrose 2.4%, MgSO 4 0.05%, KH 2 PO 4 0.1%, saturated NaHCO 3 Solution; culture method: 3 vials of strains (0.5g / bottle) were inoculated into 6 3000mL triangular flasks, the filling capacity was 500mL / bottle, sealed with kraft paper, cultured at 180r / min, 26.5°C for 2-3d, harvested, The fermentation broth was centrifuged at 2000r / min for 5min to obtain mycelium, and dried at 80°C for 24h, and the dry weight was measured. The yield of mycelium was 4.8g / 500mL. The obtained mycelium w...

Embodiment 2

[0051] Embodiment 2 clinical trials

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Abstract

The invention discloses an application of a cat isaria mycelium in the preparation for a medicine treating acute kidney injury caused by cis-platinum. An experimental result displays that after mice are injected with cis-platinum and patients are chemo-treated by cis-platinum, the CRE and BUN levels in the serums thereof are obviously increased, meaning that the cis-platinum can cause an acute kidney injury to the mice and the chemo-treated patients; after the mice injected with cis-platinum are perfused with cat isaria mycelium dry powder and the patients chemo-treated by cis-platinum take cat isaria mycelium dry powder, the CRE and BUN levels in the serums thereof are obviously decreased, meaning that the cat isaria mycelium has a remarkable treatment function to the acute kidney injury caused by cis-platinum. The invention provides the application of the cat isaria mycelium in the preparation for a medicine treating acute kidney injury caused by cis-platinum, and the cat isaria mycelium can be further developed to be an assistant medicine in the cis-platinum chemotherapy.

Description

technical field [0001] The invention relates to the application of the fungus mycelia of I. felis, in particular to the application in the preparation of medicines for treating acute kidney injury caused by cisplatin. Background technique [0002] Isaria felina (Isaria felina) is an industrially produced strain obtained from the natural Cordyceps sinensis fruiting body through strain isolation and culture. Isaria felina (DC.: Fr) Fr was identified as Isaria felina (DC.: Fr) Fr by Professor Guo Yinglan of the Institute of Microbiology, Chinese Academy of Sciences. patent. [0003] Deffieux Gerard et al. (J Antibiot (Tokyo). 1981,34 (10): 1261-1265.) extract and separate the insecticide Isariins B, C and D of ring carboxyphenolic acid peptide structure from Isaria felina, and to Isariins The structures of B, C and D were identified (J Antibiot (Tokyo). 1981, 34(10): 1266-1270.). Guo Yongxia isolated and purified the cyclic depsipeptide isarfelin with antifungal effect from ...

Claims

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Application Information

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IPC IPC(8): A61K35/06A61P13/12
Inventor 张生万杨喜花任连生
Owner SHANXI UNIV
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