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Pharmaceutical composition used for treating cerebral stroke, and preparation method thereof

A composition and stroke technology, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of lack of treatment measures, increase in stroke mortality, etc.

Active Publication Date: 2011-11-09
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The mortality rate of cerebral apoplexy also tends to rise with age, and there has been a lack of effective treatment measures for a long time. Therefore, the development of safe and effective drugs for the treatment of cerebral apoplexy is an urgent problem that needs to be solved by the medical community today.

Method used

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  • Pharmaceutical composition used for treating cerebral stroke, and preparation method thereof
  • Pharmaceutical composition used for treating cerebral stroke, and preparation method thereof
  • Pharmaceutical composition used for treating cerebral stroke, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Embodiment 1: hard capsule

[0162] Prescription: Rhodiola Rosea Extract 500g, Scrophulariaceae Extract 500g

[0163] Preparation method: (1) Take Rhodiola rosea medicinal material, reflux extraction with 70% ethanol for 2 times, each time for 2 hours, recover ethanol, add water to dissolve the concentrated solution, refrigerate and stand still, filter, and the filtrate is adsorbed by AB-8 macroporous resin , after eluting with water, then eluting with 40% ethanol, collecting the ethanol eluate, concentrating the eluate under reduced pressure, and drying in vacuum to obtain the Rhodiola rosea extract;

[0164] (2) Take Scrophulariaceae medicinal material, reflux extraction with 50% ethanol twice, each time for 2 hours, recover ethanol, concentrate to 1:1, add ethanol to the concentrated solution to make the alcohol concentration reach 75%, refrigerate and stand, filter, and filtrate Recover ethanol, add water to dissolve the concentrated solution, refrigerate and let s...

Embodiment 2

[0168] Embodiment 2: hard capsules

[0169] Prescription: Rhodiola Rosea Extract 300g, Scrophulariaceae Extract 700g

[0170] Preparation method: (1) Take rhodiola rosea medicinal material, soak and extract twice in 50% ethanol, each time for 2 hours, recover ethanol, add water to dissolve the concentrated solution, refrigerate and stand still, filter, and the filtrate is adsorbed by AB-8 macroporous resin , after eluting with water, then eluting with 40% ethanol, collecting the ethanol eluate, concentrating the eluate under reduced pressure, and drying in vacuum to obtain the Rhodiola rosea extract;

[0171] (2) Take Scrophulariaceae medicinal material, reflux extraction with 55% ethanol twice, each time for 2 hours, recover ethanol, concentrate to 1:1, add ethanol to the concentrated solution to make the alcohol concentration reach 75%, refrigerate and stand, filter, and filtrate Recover ethanol, add water to dissolve the concentrated solution, refrigerate and let stand, fi...

Embodiment 3

[0175] Embodiment 3: dropping pill

[0176] Prescription: Rhodiola Rosea Extract 300g, Scrophulariaceae Extract 700g

[0177] Preparation method: (1) Take rhodiola rosea medicinal material, reflux extraction with 60% ethanol for 2 times, each time for 2 hours, recover ethanol, add water to dissolve the concentrated solution, refrigerate and stand still, filter, and the filtrate is adsorbed by AB-8 macroporous resin , after eluting with water, then eluting with 40% ethanol, collecting the ethanol eluate, concentrating the eluate under reduced pressure, and drying in vacuum to obtain the Rhodiola rosea extract;

[0178] (2) Take Scrophulariaceae medicinal material, soak and extract 2 times in 60% ethanol, each time for 2 hours, recover ethanol, concentrate to 1:1, add ethanol to the concentrated solution to make the alcohol concentration reach 75%, refrigerate and stand, filter, and filtrate Recover ethanol, add water to dissolve the concentrated solution, refrigerate and stand...

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Abstract

The invention relates to a traditional Chinese medicine composition, and specifically relates to a pharmaceutical composition used for treating cerebral strokes. The composition is prepared from raw medicines of, by weight: 1 to 10 parts of rhodiola root extract and 1 to 10 parts of figwort root extract. The pharmaceutical composition also can be composed of, by weight: 1 to 10 parts of rhodiola root extract, 1 to 10 parts of figwort root extract, and 1 to 10 parts of salvia miltiorrhiza extract; or the pharmaceutical composition can be composed of, by weight: 1 to 10 parts of rhodiola root extract, 1 to 10 parts of figwort root extract, and 1 to 10 parts of ligusticum wallichii extract; or the pharmaceutical composition can be composed of, by weight: 1 to 10 parts of rhodiola root extract, 1 to 10 parts of figwort root extract, and 1 to 10 parts of lobed kudzuvine root extract. With regular preparation methods in pharmaceutics, the traditional Chinese medicine composition can be prepared into tablets, hard capsules, pills, granules, soft capsules, oral liquid or injections.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition, in particular to a composition of a medicinal extract capable of treating cerebral apoplexy and a preparation method thereof. technical background: [0002] Cerebral stroke is a group of diseases with cerebral ischemia and hemorrhagic injury symptoms as the main clinical manifestations, also known as stroke or cerebrovascular accident, with a very high mortality rate and disability rate, mainly divided into hemorrhagic stroke ( Cerebral hemorrhage or subarachnoid hemorrhage) and ischemic stroke (cerebral infarction, cerebral thrombosis), with cerebral infarction being the most common. Cerebral stroke is one of the most important fatal diseases in the world, with acute onset and high mortality rate. [0003] The mortality rate of cerebral apoplexy also tends to increase with age, and there has been a lack of effective treatment measures for a long time. Therefore, the development of safe and effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P9/10
Inventor 萧伟王振中张桥韩兆忠章晨峰陆华明陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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