Aromatic essential oil medicinal composition for preventing and treating hypertension and adjusting functions of internal organs through olfactory path in a brain targeted mode

A composition and technology for hypertension, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems of unclear specific action paths of essential oils, and achieve the elimination of nervous and mental tension, alleviation of mental stress, and prevention and treatment of high blood pressure. Effect

Inactive Publication Date: 2011-11-16
李光武 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of essential oil inhalation comes from the aroma molecules of essential oils, which may work through the sense of smell, but the specific pathway of action of essential oils is not clear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] This experiment also found that the blood pressure-lowering effect of lavender essential oil began to decline gradually 15 minutes after the end of inhalation, and was most obvious at 80-100 minutes after the end of inhalation, and did not return to the pre-intervention level within 100 minutes of the observation period. It shows that the antihypertensive effect occurs faster and lasts longer. This experiment found that the SP, DP and MAP of the blank group had no significant changes within 100 minutes after inhaling distilled water, and the difference was not significant (P>0.05). Compared with the blank group, SP, DP, and MAP in the lavender essential oil group, sham operation + lavender essential oil group all decreased, and SP, DP, and MAP began to decrease 15 minutes after the end of inhalation of essential oil, and the difference was significant 80-100 minutes after the end of inhalation of essential oil ; while model + lavender essential oil group SP, DP, MAP did...

Embodiment 2

[0020] Lavender essential oil lowers blood pressure through the olfactory pathway, and there are species differences

[0021] This study conducted a comparative study of four types of lavender and found that there are differences in their antihypertensive effects: eye-catching lavender and highland lavender are better, spike lavender is weaker, and capitula lavender has almost no antihypertensive effect. Among them, the antihypertensive effect of eye-catching lavender is greater than that of highland lavender. It was found that the SP, DP, and MAP of rats in the eye-catching lavender and highland lavender essential oil groups were lower than those in the blank group, while the SP, DP, and MAP of the rosemary and clove essential oil groups had no significant changes compared with the blank group. It shows that the essential oils of eye-catching lavender and highland lavender can reduce blood pressure in rats. The possible mechanism is that lavender binds to ORs on the membrane ...

Embodiment 3

[0023] Lowering blood pressure is achieved through the olfactory pathway, clarifying the scientific basis of aromatherapy for lowering blood pressure. The experimental results of inhaling different types of lavender essential oils on blood pressure after rats with damaged olfactory epithelium suggest that different types of lavender essential oils have no effect on lowering blood pressure in rats with damaged olfactory epithelium. In order to explain the above-mentioned changes, this experiment measured the changes of peripheral blood catecholamines after inhaling different types of lavender essential oils; Analysis to explore the possible mechanism of lavender essential oil lowering blood pressure.

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PUM

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Abstract

The invention discloses an aromatic essential oil medicinal composition for preventing and treating hypertension and adjusting functions of internal organs through an olfactory path in a brain targeted mode. The composition comprises lavandula burnatii and highland lavender and also comprises the following pharmacological active ingredients of lavender ester, acetic lavender ester and any mixture of an isomer thereof, or lavender essential oil which can be directly used, wherein other natural flavors can also be added. In the aromatic essential oil medicinal composition, the plant essential oil and the active ingredients thereof stimulate olfactory neurons through a nose and an oral cavity, regulate and control a brain olfactory center and hypothalamus through the olfactory path, directly perform brain targeting, aim at a hypertension action mechanism, and can be used for preventing and treating hypertension, remitting mental pressure and eliminating nervous and mental tension.

Description

technical field [0001] The invention belongs to the field of medical health care and aromatherapy essential oil efficacy, and specifically relates to lavender essential oil, lavender ester, acetyl lavender ester and a prescription formed or a main component thereof used in the preparation of medicines for preventing and treating high blood pressure, relieving mental stress and improving brain function and its application in new formulations. Background technique [0002] Hypertension is currently the most common cardiovascular disease, which can lead to a series of serious diseases such as coronary heart disease, stroke, congestive heart failure and renal failure. Cardiovascular and cerebrovascular diseases cause 12 million deaths every year in the world, seriously threatening human health, and have become one of the important public health problems. According to the global burden of disease survey, 50% of cardiovascular diseases are caused by high blood pressure, and hyper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/231A61K36/53A61K31/37A61P9/12
Inventor 李光武杨爱红徐蓉任振华王海萍刘莉茵徐金勇
Owner 李光武
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