Preparation process of alkaloid tabersonine

A preparation process and the technology of taponin, which are applied in the field of preparation process of alkaloid taponin, can solve the problems of high cost, unfavorable large-scale production, difficulty in purification and purification and separation of resin column, etc. Effect
CN102250092AInactive Publication Date: 2011-11-23ZHANGJIAKOU GERUI HIGH TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHANGJIAKOU GERUI HIGH TECH
Publication Date
2011-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation process of alkaloid tabersonine, relating to the technical field of biopharmaceuticals. The traditional biological preparation process of the tabersonine has the problems of large solvent loss amount, high cost, large water consumption, high adsorbent resin price, and the like. The preparation process of the alkaloid tabersonine, disclosed by the invention, comprises the following steps of: squeezing voacanga seeds; carrying out solvent extraction; carrying out acid water extraction and washing; and carrying out acid water purification, alkalinization and extraction. According to the preparation process disclosed by the invention, solvent dimethylbenzene which has high boiling point, low cost and easiness in obtaining is adopted as an extractant, anda mode of the acid water extraction and washing is adopted, and therefore, the using amount and the treatment capacity of acid water are reduced; extracted diluted acid water is treated by adopting the dimethylbenzene, and therefore the adsorption washing or repeated salt transformation purification process of the conventional macroporous resin is saved; the content of the tabersonine reaches more than 98 percent, and the extraction ratio is between 1.8 percent and 2.0 percent; in addition, according to the invention, production cost is reduced, and water consumption and solvent consumption are reduced.
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Description

technical field

[0001] The invention relates to the technical field of biopharmaceuticals, in particular to a preparation process of the alkaloid tabonin. Background technique

[0002] Tabonin, English name Tabersonine, CAS NO 4429-63-4, its chemical name is Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-(5α,12β,19γ)-methyl seter, and its molecular formula is C 21 h 24 N 2 o 2， The molecular weight is 336.42. Usually oily liquid, white powder solid with higher purity, its hydrochloride is C 21 h 24 N 2 o 2 HCl, melting point is 196°C, [α] D 25 -318 。 (C=0.58, ethanol), IR: λcm -1 : 3365, 1690, 1630, 1615; UVλmax (Loge): 228 (4.03), 298 (4.02), 331 (4.16).

[0003] Boning is a good medicinal material, which has antihypertensive, antitumor, hypoglycemic and diuretic effects, and is used for depression, anxiety and emotional instability caused by stroke sequelae, ischemic hypertensive encephalopathy and cerebrovascular disease. It is suitable for elimina...

Claims

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