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Application of dihydroarylnaphthalene lignan derivatives and their compositions in the preparation of drugs for preventing and treating mammary gland hyperplasia

A technology of mammary gland hyperplasia and derivatives, applied in the directions of drug combination, active ingredients of aldehydes, sexual diseases, etc., to achieve the effect of good therapeutic effect

Inactive Publication Date: 2011-11-30
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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But only the extraction and structure of the compound are disclosed

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  • Application of dihydroarylnaphthalene lignan derivatives and their compositions in the preparation of drugs for preventing and treating mammary gland hyperplasia
  • Application of dihydroarylnaphthalene lignan derivatives and their compositions in the preparation of drugs for preventing and treating mammary gland hyperplasia
  • Application of dihydroarylnaphthalene lignan derivatives and their compositions in the preparation of drugs for preventing and treating mammary gland hyperplasia

Examples

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Effect test

Embodiment 1

[0028] Effects of compounds and compositions provided by the invention on experimental rat mammary gland hyperplasia.

[0029] The test animals are SD rats, 150-200 g, 108 females. All were provided by Dongchuang Experimental Animal Science and Technology Service Department, Kaifu District, Changsha City, Hunan Province, experimental animal production license: SCXK (Xiang) No. ) No. 2003-2006. The temperature in the laboratory was 18-28°C, and the rats were fed with self-made standard pellet feed, and they had free access to food and water.

[0030] The rat model of mammary gland hyperplasia was established by intramuscular injection of estradiol benzoate combined with progesterone. After the animals were weighed, 0.5 mg / kg of estradiol benzoate injection was intramuscularly injected once a day for 25 consecutive days, and progesterone 5 mg / kg was injected intramuscularly once a day for 5 consecutive days. The normal control group was injected intramuscularly with 0.2ml of ...

Embodiment 2

[0054] Effects of compound 3 and compositions provided by the present invention on experimental rabbit mammary gland hyperplasia.

[0055] Experimental animals SD rabbits, 2.0-3.0kg, 90, female. All were provided by Dongchuang Experimental Animal Science and Technology Service Department, Kaifu District, Changsha City, Hunan Province, experimental animal production license: SCXK (Xiang) No. ) No. 2003-2006. The temperature in the laboratory was 18-28°C, and the rats were fed with self-made standard pellet feed, and they had free access to food and water.

[0056] The rabbit model of mammary gland hyperplasia was established by intramuscular injection of estradiol benzoate. After the animals were weighed, 0.5 mg / kg of estradiol benzoate injection was intramuscularly injected once a day for 30 consecutive days. The normal control group was intramuscularly injected with 1.0ml of normal saline for 30 days, once a day.

[0057] Rabbits were randomly divided into 9 groups: norma...

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Abstract

The invention relates to application of a dihydro arylnaphthalene lignan derivative and a composition thereof to preparing a medicament for preventing and treating hyperplasia of mammary glands. The dihydro arylnaphthalene lignan derivative has a structure which is shown in a formula I.

Description

field of invention [0001] The invention relates to a class of dihydroaryl naphthalene lignan compounds and the application of the composition thereof. Background of the invention [0002] Lignan, also known as lignan, is a class of compounds formed by the polymerization of two molecules of phenylpropanoid derivatives (C6-C3). Lignans are widely distributed, and there are more than 200 kinds of compounds. In recent years, trimers and tetramers have also been found. [0003] Since lignans with new structures have been discovered one after another, lignans are divided into lignans and neolignans. Where by C 6 -C 3 The lignans formed by connecting the b-carbon atoms on the side chains of the units are called lignans, while the lignans formed by connecting other positions are called new lignans. In recent years, the classification definition refers to the lignans generated from γ-carbon atom oxidized phenylpropanoid as lignans (composed of two monomers, cinnamic acid, cinnami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/11A61P15/14
Inventor 周美辰何熙周应军曾光尧史跃年
Owner CENT SOUTH UNIV
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